Mutations in the TP53 tumour suppressor gene are very frequent in cancer, and attempts to
restore the functionality of p53 in tumours as a therapeutic strategy began decades ago …

The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

Various physiological processes involve appropriate tissue developmental process and
homeostasis-the pathogenesis of several diseases connected with deregulatory apoptosis …

The tumour suppressor gene TP53 is the most frequently mutated gene in cancer. Wild-type
p53 can suppress tumour development by multiple pathways. However, mutation of TP53 …

Mutations in the TP53 tumour suppressor gene are found in~ 50% of human cancers [,,,,–].
TP53 functions as a transcription factor that directly regulates the expression of~ 500 genes …

TP53, which encodes the tumour-suppressor protein p53, is the most frequently mutated
gene across all cancer types. The presence of mutant p53 predisposes to cancer …

Abstract p53 is one of the most well-studied tumor suppressors. It is mutated or deleted in
half of all cancers. In the other half carrying wild type p53, the p53 signaling pathway is …

p53 is an important tumor suppressor gene, which is stimulated by cellular stress like
ionizing radiation, hypoxia, carcinogens, and oxidative stress. Upon activation, p53 leads to …

Exposure to cellular stress can trigger the p53 tumor suppressor, a sequence-specific
transcription factor, to induce cell growth arrest or apoptosis. The choice between these …

Activation of the p53 protein protects the organism against the propagation of cells that carry
damaged DNA with potentially oncogenic mutations. MDM2, a p53-specific E3 ubiquitin …