According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

The brain is expensive, incurring high material and metabolic costs for its size—relative to
the size of the body—and many aspects of brain network organization can be mostly …

In the post-genomic era, the elucidation of the relationship between the molecular origins of
diseases and their resulting phenotypes is a crucial task for medical research. Here, we use …

We review the evolution and structure of members of the transforming growth factor β (TGF-
β) family, antagonistic or agonistic modulators, and receptors that regulate TGF-β signaling …

Complex biological systems and cellular networks may underlie most genotype to
phenotype relationships. Here, we review basic concepts in network biology, discussing …

Notch signalling links the fate of one cell to that of an immediate neighbour and
consequently controls differentiation, proliferation and apoptotic events in multiple metazoan …

Macromolecular complexes are essential to conserved biological processes, but their
prevalence across animals is unclear. By combining extensive biochemical fractionation …

A key aim of postgenomic biomedical research is to systematically catalogue all molecules
and their interactions within a living cell. There is a clear need to understand how these …

Rapid technological advances have led to the production of different types of biological data
and enabled construction of complex networks with various types of interactions between …

Access to unified datasets of protein and genetic interactions is critical for interrogation of
gene/protein function and analysis of global network properties. BioGRID is a freely …