The adult skeleton regenerates by temporary cellular structures that comprise teams of
juxtaposed osteoclasts and osteoblasts and replace periodically old bone with new. A …

The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …

Osteoclasts have traditionally been associated exclusively with catabolic functions that are a
prerequisite for bone resorption. However, emerging data suggest that osteoclasts also carry …

Intravital two-photon microscopy enables deep-tissue imaging at high temporospatial
resolution in live animals. However, the endosteal bone compartment and underlying bone …

This chapter describes the isolation of primary mouse osteoblasts from adult mouse calvaria
and long bones, as well as the process of isolation of bone cells from neonatal mouse …

Primary biliary cholangitis (PBC) is an autoimmune disease characterized by the destruction
of intrahepatic small bile ducts and the presence of antimitochondrial antibody (AMA) …

Screening gene function in vivo is a powerful approach to discover novel drug targets. We
present high-throughput screening (HTS) data for 3 762 distinct global gene knockout (KO) …

Resorption of mineralized tissues like bone is accomplished by a unique cell type: the
osteoclast. This multinucleated cell has the capacity to dissolve the mineral by lowering the …

Bio-silica represents the main mineral component of the sponge skeletal elements (siliceous
spicules), while bio-polyphosphate (bio-polyP), a multifunctional polymer existing in …

During bone resorption, the osteoclast must sustain an extraordinarily low pH environment,
withstand immense ionic pressures, and coordinate nutrient and waste exchange across its …