Cancer stem cells and chemoresistance: The smartest survives the raid

J Zhao - Pharmacology & therapeutics, 2016 - Elsevier
Chemoresistant metastatic relapse of minimal residual disease plays a significant role for
poor prognosis of cancer. Growing evidence supports a critical role of cancer stem cell …

The role of snail in EMT and tumorigenesis

Y Wang, J Shi, K Chai, X Ying… - Current cancer drug …, 2013 - ingentaconnect.com
Epithelial-mesenchymal transition (EMT) is a highly conserved process in which polarized,
immobile epithelial cells lose tight junctions, associated adherence, and become migratory …

[HTML][HTML] The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer

WC Liang, WM Fu, CW Wong, Y Wang, WM Wang… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Recently, the long non-coding RNA (lncRNA) H19 has been identified as an oncogenic
gene in multiple cancer types and elevated expression of H19 was tightly linked to …

The basics of epithelial–mesenchymal transition (EMT): A study from a structure, dynamics, and functional perspective

V Das, S Bhattacharya… - Journal of cellular …, 2019 - Wiley Online Library
Epithelial–mesenchymal transition (EMT) is a key step in transdifferentiation process in solid
cancer development. Forthcoming evidence suggest that the stratified program transforms …

Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance

G Xiong, RL Stewart, J Chen, T Gao, TL Scott… - Nature …, 2018 - nature.com
Abstract Collagen prolyl 4-hydroxylase (P4H) expression and collagen hydroxylation in
cancer cells are necessary for breast cancer progression. Here, we show that P4H alpha 1 …

Diabetes and cancer: a review of current knowledge

J Wojciechowska, W Krajewski… - Experimental and …, 2016 - thieme-connect.com
Diabetes mellitus (DM), one of the most common life-threatening illnesses worldwide, is a
group of metabolic diseases, characterized by sustained hyperglycemia. The global …

The regulatory role of microRNAs in EMT and cancer

A Zaravinos - Journal of oncology, 2015 - Wiley Online Library
The epithelial to mesenchymal transition (EMT) is a powerful process in tumor invasion,
metastasis, and tumorigenesis and describes the molecular reprogramming and phenotypic …

The role of CD44 in disease pathophysiology and targeted treatment

AR Jordan, RR Racine, MJP Hennig… - Frontiers in …, 2015 - frontiersin.org
The cell-surface glycoprotein CD44 is involved in a multitude of important physiological
functions including cell proliferation, adhesion, migration, hematopoiesis, and lymphocyte …

Transcription factors that mediate epithelial–mesenchymal transition lead to multidrug resistance by upregulating ABC transporters

M Saxena, MA Stephens, H Pathak… - Cell death & disease, 2011 - nature.com
Abstract Development of multidrug resistance (MDR) is a major deterrent in the effective
treatment of metastatic cancers by chemotherapy. Even though MDR and cancer …

Epithelial-mesenchymal transition: general principles and pathological relevance with special emphasis on the role of matrix metalloproteinases

P Nisticò, MJ Bissell… - Cold Spring Harbor …, 2012 - cshperspectives.cshlp.org
Epithelial-mesenchymal transition (EMT) is a physiological process in which epithelial cells
acquire the motile and invasive characteristics of mesenchymal cells. Although EMT in …