Degenerative cervical myelopathy: Where have we been? Where are we now? Where are we going?

N Hejrati, K Pedro, MA Alvi, A Quddusi… - Acta Neurochirurgica, 2023 - Springer
Degenerative cervical myelopathy (DCM), a recently coined term, encompasses a group of
age-related and genetically associated pathologies that affect the cervical spine, including …

A global view of aging and Alzheimer's pathogenesis-associated cell population dynamics and molecular signatures in human and mouse brains

A Sziraki, Z Lu, J Lee, G Banyai, S Anderson… - Nature Genetics, 2023 - nature.com
Conventional methods fall short in unraveling the dynamics of rare cell types related to
aging and diseases. Here we introduce EasySci, an advanced single-cell combinatorial …

Clinical trials for neuroregenerative therapies for spinal cord injury: what have we learnt so far?

R Wong, N Hejrati, MG Fehlings - Expert Review of …, 2023 - Taylor & Francis
Introduction There remains a lack of effective regenerative therapies to treat traumatic spinal
cord injury (SCI). On a global level, patients living with SCI, their families, and the healthcare …

[HTML][HTML] Neuromotor decline is associated with gut dysbiosis following surgical decompression for Degenerative Cervical Myelopathy

PM Vidal, S Brockie, C Farkas, J Hong, C Zhou… - Neurobiology of …, 2024 - Elsevier
Degenerative cervical myelopathy (DCM) describes a spectrum of disorders that cause
progressive and chronic cervical spinal cord compression. The clinical presentation can be …

Degenerative Cervical Myelopathy induces sex-specific dysbiosis in mice

C Farkas, E Retamal-Fredes, A Ávila… - Frontiers in …, 2023 - frontiersin.org
Degenerative Cervical Myelopathy (DCM) is the most common cause of spinal cord
impairment in elderly populations. It describes a spectrum of disorders that cause …

[HTML][HTML] Resident immune responses to spinal cord injury: role of astrocytes and microglia

S Brockie, C Zhou, MG Fehlings - Neural Regeneration Research, 2024 - journals.lww.com
Spinal cord injury can be traumatic or non-traumatic in origin, with the latter rising in
incidence and prevalence with the aging demographics of our society. Moreover, as the …

Acute systemic white blood cell changes following degenerative cervical myelopathy (DCM) in a mouse model

A Ulndreaj, A Ávila, J Hong, C Zhou… - International Journal of …, 2022 - mdpi.com
Degenerative cervical myelopathy (DCM) is caused by age-related degeneration of the
cervical spine, causing chronic spinal cord compression and inflammation. The aim of this …

Impaired communication at the neuromotor axis during Degenerative Cervical Myelopathy

J Ojeda, M Vergara, A Ávila, JP Henríquez… - Frontiers in Cellular …, 2024 - frontiersin.org
Degenerative Cervical Myelopathy (DCM) is a progressive neurological condition
characterized by structural alterations in the cervical spine, resulting in compression of the …

Mapping the Degenerative Cervical Myelopathy Research Landscape: Topic Modeling of the Literature

M Karabacak, P Jagtiani, CM Zipser… - Global Spine …, 2024 - journals.sagepub.com
Study Design Topic modeling of literature. Objectives Our study has 2 goals:(i) to clarify key
themes in degenerative cervical myelopathy (DCM) research, and (ii) to evaluate the current …

Synaptojanin 1 Modulates Functional Recovery After Incomplete Spinal Cord Injury in Male Apolipoprotein E Epsilon 4 Mice

CA Toro, J Hansen, MM Siddiq, K Johnson… - Neurotrauma …, 2023 - liebertpub.com
Abstract Apolipoprotein E epsilon 4 (ApoE4) is the second most common variant of ApoE,
being present in∼ 14% of the population. Clinical reports identify ApoE4 as a genetic risk …