Redox processes are at the heart of synthetic methods that rely on either electrochemistry or
photoredox catalysis, but how do electrochemistry and photoredox catalysis compare? Both …

The synthesis of amides is extremely important given the ubiquitous presence of this motif in
biological systems, as well as in the pharmaceutical industry, where it is estimated that …

Photocatalysis in aqueous micellar media has recently opened wide avenues to activate
strong carbon–halide bonds. So far, however, it has mainly explored strongly reducing …

Oxidation is the main pathway of drug metabolism and cytochrome P-450 (CYP450)
enzymes account for over 80% of drug oxidation. The chemical outcome of this first-pass …

In this concise review, the field of electrosynthesis (ES) as a green methodology for
understanding drug metabolites linked to toxicology is exemplified. ES describes the …

This review discusses the state of the art, challenges, and perspectives in recent
applications of nitroaromatics and nitroheteroaromatics, which are redox-bio-activated drugs …

The electrochemical Shono oxidation of Boc‐protected cyclic amines was revised. The
conditions for scalable electrochemical synthesis of cyclic enecarbamates were found. The …

Over the last 3 decades, electrochemistry (EC) has been successfully applied in phase I and
phase II metabolism simulation studies. The electrochemically generated phase I metabolite …

The tractable preparation of Phase I drug metabolites is a critical step to understand the first-
pass behaviour of novel chemical entities (NCEs) in drug discovery. In this study, we have …

The integration of electrochemistry with nuclear magnetic resonance (NMR) spectroscopy
recently offers a powerful approach to understanding oxidative metabolism, detecting …