Disease heterogeneity in amyotrophic lateral sclerosis poses a substantial challenge in drug
development. Categorization based on clinical features alone can help us predict the …

Magnetic resonance spectroscopy (MRS) has contributed important academic insights in
motor neuron diseases (MNDs), particularly in amyotrophic lateral sclerosis (ALS). Over the …

Amyotrophic lateral sclerosis (ALS) is associated with considerable clinical heterogeneity
spanning from diverse disability profiles, differences in UMN/LMN involvement, divergent …

Background: Magnetic resonance spectroscopy (MRS) in amyotrophic lateral sclerosis
(ALS) has been overwhelmingly applied to motor regions to date and our understanding of …

Background The characterisation of presymptomatic disease-burden patterns in
asymptomatic mutation carriers has a dual academic and clinical relevance. The …

Background and purpose Primary lateral sclerosis (PLS) is a progressive upper motor
neuron disorder associated with considerable clinical disability. Symptoms are typically …

Background Bulbar dysfunction is a cardinal feature of ALS with important quality of life and
management implications. The objective of this study is the longitudinal evaluation of a large …

Background Frontotemporal dementia (FTD) phenotypes are classically associated with
distinctive cortical atrophy patterns and regional hypometabolism. However, the spectrum of …

Multimodal data play an important role in the diagnosis of brain diseases. This study
constructs a whole-brain functional connectivity network based on functional MRI data, uses …

Introduction Amyotrophic lateral sclerosis (ALS) is a rare and fatal neurological disease that
leads to progressive motor function degeneration. Diagnosing ALS is challenging due to the …