The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis
A Shilatifard - Annual review of biochemistry, 2012 - annualreviews.org
The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4)
methylase identified over 10 years ago. Since then, it has been demonstrated that …
methylase identified over 10 years ago. Since then, it has been demonstrated that …
The complex language of chromatin regulation during transcription
SL Berger - Nature, 2007 - nature.com
An important development in understanding the influence of chromatin on gene regulation
has been the finding that DNA methylation and histone post-translational modifications lead …
has been the finding that DNA methylation and histone post-translational modifications lead …
Chromatin-and transcription-related factors repress transcription from within coding regions throughout the Saccharomyces cerevisiae genome
Previous studies in Saccharomyces cerevisiae have demonstrated that cryptic promoters
within coding regions activate transcription in particular mutants. We have performed a …
within coding regions activate transcription in particular mutants. We have performed a …
Human TFIIH kinase CDK7 regulates transcription-associated chromatin modifications
CDK7 phosphorylates the RNA polymerase II (pol II) C-terminal domain CTD and activates
the P-TEFb-associated kinase CDK9, but its regulatory roles remain obscure. Here, using …
the P-TEFb-associated kinase CDK9, but its regulatory roles remain obscure. Here, using …
SMYD5 catalyzes histone H3 lysine 36 trimethylation at promoters
Y Zhang, Y Fang, Y Tang, S Han, J Jia, X Wan… - Nature …, 2022 - nature.com
Histone marks, carriers of epigenetic information, regulate gene expression. In mammalian
cells, H3K36me3 is mainly catalyzed by SETD2 at gene body regions. Here, we find that in …
cells, H3K36me3 is mainly catalyzed by SETD2 at gene body regions. Here, we find that in …
Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex
Y Liu, L Warfield, C Zhang, J Luo, J Allen… - … and cellular biology, 2009 - Taylor & Francis
The Saccharomyces cerevisiae kinase Bur1 is involved in coupling transcription elongation
to chromatin modification, but not all important Bur1 targets in the elongation complex are …
to chromatin modification, but not all important Bur1 targets in the elongation complex are …
A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation
S Nakanishi, BW Sanderson, KM Delventhal… - Nature structural & …, 2008 - nature.com
Methylation of histone 3 lysine 4 (H3K4) by yeast Set1-COMPASS requires prior
monoubiquitination of histone H2B. To define whether other residues within the histones are …
monoubiquitination of histone H2B. To define whether other residues within the histones are …
Modes of interaction of KMT2 histone H3 lysine 4 methyltransferase/COMPASS complexes with chromatin
A Bochynska, J Lüscher-Firzlaff, B Lüscher - Cells, 2018 - mdpi.com
Regulation of gene expression is achieved by sequence-specific transcriptional regulators,
which convey the information that is contained in the sequence of DNA into RNA …
which convey the information that is contained in the sequence of DNA into RNA …
Phosphorylation of the Pol II CTD by KIN28 enhances BUR1/BUR2 recruitment and Ser2 CTD phosphorylation near promoters
H Qiu, C Hu, AG Hinnebusch - Molecular cell, 2009 - cell.com
Cyclin-dependent kinase BUR1/BUR2 appears to be the yeast ortholog of P-TEFb, which
phosphorylates Ser2 of the RNA Pol II CTD, but the importance of BUR1/BUR2 in CTD …
phosphorylates Ser2 of the RNA Pol II CTD, but the importance of BUR1/BUR2 in CTD …