Targeting natural killer cells and natural killer T cells in cancer
Natural killer (NK) cells and natural killer T (NKT) cells are subsets of lymphocytes that share
some phenotypical and functional similarities. Both cell types can rapidly respond to the …
some phenotypical and functional similarities. Both cell types can rapidly respond to the …
Improving outcomes in chronic myeloid leukemia through harnessing the immunological landscape
The quest for treatment-free remission (TFR) and deep molecular response (DMR) in
chronic myeloid leukemia (CML) has been profoundly impacted by tyrosine kinase inhibitors …
chronic myeloid leukemia (CML) has been profoundly impacted by tyrosine kinase inhibitors …
Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR …
The introduction in 1998 of imatinib mesylate (IM) revolutionized management of patients
with chronic myeloid leukemia (CML) and the second generation of tyrosine kinase …
with chronic myeloid leukemia (CML) and the second generation of tyrosine kinase …
The graft-versus-leukemia effect in AML
C Sweeney, P Vyas - Frontiers in oncology, 2019 - frontiersin.org
Allogeneic hematopoietic stem cell transplantation (allo-SCT) is the most established and
commonly used cellular immunotherapy in cancer care. It is the most potent anti-leukemic …
commonly used cellular immunotherapy in cancer care. It is the most potent anti-leukemic …
Graft-versus-leukemia effect following hematopoietic stem cell transplantation for leukemia
AM Dickinson, J Norden, S Li, I Hromadnikova… - Frontiers in …, 2017 - frontiersin.org
The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the
engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia …
engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia …
Risk stratification–directed donor lymphocyte infusion could reduce relapse of standard-risk acute leukemia patients after allogeneic hematopoietic stem cell …
CH Yan, DH Liu, KY Liu, LP Xu, YR Liu… - Blood, The Journal …, 2012 - ashpublications.org
We studied the impact of risk stratification–directed interventions for minimal residual
disease (MRD) on relapse and disease-free survival (DFS) prospectively in 814 subjects …
disease (MRD) on relapse and disease-free survival (DFS) prospectively in 814 subjects …
Graft-versus-leukemia reactions in allogeneic chimeras
HJ Kolb, C Schmid, AJ Barrett, DJ Schendel - Blood, 2004 - ashpublications.org
There is a strong graft-versus-leukemia (GVL) effect of allogeneic stem cell transplantation
(SCT) due to elimination of tumor cells by alloimmune effector lymphocytes. When leukemia …
(SCT) due to elimination of tumor cells by alloimmune effector lymphocytes. When leukemia …
Allogeneic hematopoietic stem cell transplantation for chronic myeloid leukemia in Europe 2006: transplant activity, long-term data and current results. An analysis by …
A Gratwohl, R Brand, J Apperley, C Crawley… - …, 2006 - haematologica.org
The introduction of imatinib mesylate has changed attitudes towards hematopoietic stem cell
transplantation (HSCT) for chronic myeloid leukemia (CML). Information on the current use …
transplantation (HSCT) for chronic myeloid leukemia (CML). Information on the current use …
Prospective trial of chemotherapy and donor leukocyte infusions for relapse of advanced myeloid malignancies after allogeneic stem-cell transplantation
PURPOSE: Patients with advanced myeloid malignancies who experience relapse after
allogeneic bone marrow transplantation (BMT) have a poor prognosis. Long-term survival …
allogeneic bone marrow transplantation (BMT) have a poor prognosis. Long-term survival …
Second transplant for acute and chronic leukemia relapsing after first HLA-identical sibling transplant
M Eapen, SA Giralt, MM Horowitz, JP Klein… - Bone marrow …, 2004 - nature.com
Treatment options for persons with leukemia relapsing after allogeneic transplantation are
limited. We analyzed the outcome of 279 patients with acute and chronic leukemia, who …
limited. We analyzed the outcome of 279 patients with acute and chronic leukemia, who …