Long COVID as a disease of accelerated biological aging: An opportunity to translate geroscience interventions
A Shafqat, MC Masters, U Tripathi, T Tchkonia… - Ageing Research …, 2024 - Elsevier
It has been four years since long COVID—the protracted consequences that survivors of
COVID-19 face—was first described. Yet, this entity continues to devastate the quality of life …
COVID-19 face—was first described. Yet, this entity continues to devastate the quality of life …
Heart failure with preserved ejection fraction epidemiology, pathophysiology, diagnosis and treatment strategies
A Abdin, M Böhm, B Shahim, P Karlström… - International Journal of …, 2024 - Elsevier
The prevalence of HF with preserved ejection raction (HFpEF, with EF≥ 50%) is increasing
across all populations with high rates of hospitalization and mortality, reaching up to 80 …
across all populations with high rates of hospitalization and mortality, reaching up to 80 …
Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT …
BA Borlaug, MR Zile, CM Kramer, SJ Baum, K Hurt… - Nature Medicine, 2024 - nature.com
Patients with obesity-related heart failure with preserved ejection fraction (HFpEF) display
circulatory volume expansion and pressure overload contributing to cardiovascular–kidney …
circulatory volume expansion and pressure overload contributing to cardiovascular–kidney …
Semaglutide and NT-proBNP in obesity-related HFpEF: insights from the STEP-HFpEF program
Background The glucagon-like peptide-1 receptor agonist, semaglutide, improved health
status and reduced body weight in patients with obesity-related heart failure (HF) with …
status and reduced body weight in patients with obesity-related heart failure (HF) with …
Inflammation in obesity-related HFpEF: the STEP-HFpEF program
Background Inflammation is thought to be an important mechanism for the development and
progression of obesity-related heart failure with preserved ejection fraction (HFpEF). In the …
progression of obesity-related heart failure with preserved ejection fraction (HFpEF). In the …
Interleukin-6 and cardiovascular events in healthy adults: MESA
MS Khan, KM Talha, MH Maqsood, JA Rymer… - JACC: Advances, 2024 - jacc.org
Abstract Background Elevated interleukin (IL)-6 levels have been linked to adverse
outcomes in patients with and without baseline cardiovascular disease (CVD). Objectives …
outcomes in patients with and without baseline cardiovascular disease (CVD). Objectives …
IL‐6 and hsCRP predict cardiovascular mortality in patients with heart failure with preserved ejection fraction
M Berger, W März, A Niessner, G Delgado… - ESC Heart …, 2024 - Wiley Online Library
Aims Inflammation accompanies heart failure (HF) and elevated levels of inflammatory
biomarkers are linked to new onset of HF. However, whether the prognostic relevance of …
biomarkers are linked to new onset of HF. However, whether the prognostic relevance of …
Imaging and mechanisms of heart failure with preserved ejection fraction: a state-of-the-art review
Understanding of the pathophysiology of heart failure with preserved ejection fraction
(HFpEF) has advanced rapidly over the past two decades. Currently, HFpEF is recognized …
(HFpEF) has advanced rapidly over the past two decades. Currently, HFpEF is recognized …
A novel controlled metabolic accelerator for the treatment of obesity‐related heart failure with preserved ejection fraction: Rationale and design of the Phase 2a …
Aims Compared with those without obesity, patients with obesity‐related heart failure with
preserved ejection fraction (HFpEF) have worse symptoms, haemodynamics, and outcomes …
preserved ejection fraction (HFpEF) have worse symptoms, haemodynamics, and outcomes …
Acute-on-chronic inflammation in acute myocardial infarction
MA Matter, T Tschaikowsky, BE Stähli… - Current Opinion in …, 2024 - journals.lww.com
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