Therapeutically harnessing extracellular vesicles
The field of extracellular vesicle (EV) research has developed rapidly over the last decade
from the study of fundamental biology to a subject of significant clinical relevance. The …
from the study of fundamental biology to a subject of significant clinical relevance. The …
[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?
M Kou, L Huang, J Yang, Z Chiang, S Chen, J Liu… - Cell Death & …, 2022 - nature.com
Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone
marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and …
marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and …
[HTML][HTML] Recent updates of diagnosis, pathophysiology, and treatment on osteoarthritis of the knee
S Jang, K Lee, JH Ju - International journal of molecular sciences, 2021 - mdpi.com
Osteoarthritis (OA) is a degenerative and chronic joint disease characterized by clinical
symptoms and distortion of joint tissues. It primarily damages joint cartilage, causing pain …
symptoms and distortion of joint tissues. It primarily damages joint cartilage, causing pain …
[HTML][HTML] Mesenchymal stem cells and immunomodulation: current status and future prospects
F Gao, SM Chiu, DAL Motan, Z Zhang, L Chen… - Cell death & …, 2016 - nature.com
The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them
an invaluable cell type for the repair of tissue/organ damage caused by chronic inflammation …
an invaluable cell type for the repair of tissue/organ damage caused by chronic inflammation …
[HTML][HTML] Applications of mesenchymal stem cells in skin regeneration and rejuvenation
Mesenchymal stem cells (MSCs) are multipotent stem cells derived from adult stem cells.
Primary MSCs can be obtained from diverse sources, including bone marrow, adipose …
Primary MSCs can be obtained from diverse sources, including bone marrow, adipose …
[HTML][HTML] Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration
Objective Clinical and animal studies have demonstrated the efficacy of mesenchymal stem
cell (MSC) therapies in cartilage repair. As the efficacy of many MSC-based therapies has …
cell (MSC) therapies in cartilage repair. As the efficacy of many MSC-based therapies has …
Mesenchymal stem cells secrete immunologically active exosomes
Mesenchymal stem cells (MSCs) have been shown to secrete exosomes that are
cardioprotective. Here, we demonstrated that MSC exosome, a secreted membrane vesicle …
cardioprotective. Here, we demonstrated that MSC exosome, a secreted membrane vesicle …
Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery
Advances in biomedical research have generated an unprecedented number of potential
targets for therapeutic intervention to treat disease or delay disease progression …
targets for therapeutic intervention to treat disease or delay disease progression …
[HTML][HTML] Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
Human ESC-derived mesenchymal stem cell (MSC)-conditioned medium (CM) was
previously shown to mediate cardioprotection during myocardial ischemia/reperfusion injury …
previously shown to mediate cardioprotection during myocardial ischemia/reperfusion injury …
Proteolytic potential of the MSC exosome proteome: Implications for an exosome‐mediated delivery of therapeutic proteasome
Mesenchymal stem cells (MSCs) are used in many of the current stem cell‐based clinical
trials and their therapeutic efficacy has increasingly been attributed to secretion of paracrine …
trials and their therapeutic efficacy has increasingly been attributed to secretion of paracrine …