Phthalates are chemicals widely used in industry and the consequences for human health
caused by exposure to these agents are of significant current interest. Phthalate toxicity …

Airway smooth muscle (ASM) extends from the trachea throughout the bronchial tree to the
terminal bronchioles. In utero, spontaneous phasic contraction of fetal ASM is critical for …

Asthma, a common disorder that affects> 250 million people worldwide, is defined by
exaggerated bronchoconstriction to inflammatory mediators including acetylcholine (ACh) …

As cells with aberrant force-generating phenotypes can directly lead to disease, cellular
force-generation mechanisms are high-value targets for new therapies. Here, we show that …

Aim We analyze and discuss the clinical presentation, the diagnostic procedures and the
surgical technique in relation to post-operative complications and results in cervico …

Mitochondria are autonomous cellular organelles that oversee a variety of functions such as
metabolism, energy production, calcium buffering and cell fate determination. Regulation of …

Fibrostenosing Crohn's disease (CD) represents a challenging clinical condition
characterized by the development of symptomatic strictures within the gastrointestinal tract …

Airway diseases such as asthma involve increased airway smooth muscle (ASM)
contractility and remodelling via enhanced proliferation. Neurotrophins (NTs) such as brain …

Airway smooth muscle (ASM) cell hyperplasia driven by persistent inflammation is a
hallmark feature of remodeling in asthma. Sex steroid signaling in the lungs is of …

ABSTRACT Gα q βγ heterotrimer (G q), an important mediator in the pathology of airway
disease, plays a central role in bronchoconstriction and airway remodeling, including airway …