Biocatalysis making waves in organic chemistry

U Hanefeld, F Hollmann, CE Paul - Chemical Society Reviews, 2022 - pubs.rsc.org
Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

Enantioselective enzymatic desymmetrizations in organic synthesis

E García-Urdiales, I Alfonso, V Gotor - Chemical Reviews, 2005 - ACS Publications
During the recent past years, tremendous efforts have been made to establish
enantioselective routes for the preparation of enantiomerically pure compounds due to their …

Emerging enzymes for ATP regeneration in biocatalytic processes

JN Andexer, M Richter - ChemBioChem, 2015 - Wiley Online Library
Abstract Adenosine‐5′‐triphosphate‐dependent enzyme catalysed reactions are
widespread in nature. Consequently, the enzymes involved have an intrinsic potential for …

Engineered enzymes that retain and regenerate their cofactors enable continuous-flow biocatalysis

CJ Hartley, CC Williams, JA Scoble, QI Churches… - Nature Catalysis, 2019 - nature.com
Biocatalysis is an attractive route for the synthesis of complex organic molecules, such as
pharmaceuticals, due to the properties of enzymes (high specificity and high catalytic rate) …

C− C bond-forming lyases in organic synthesis

M Brovetto, D Gamenara, P Saenz Mendez… - Chemical …, 2011 - ACS Publications
Lyases are enzymes that catalyze the bond construction and breaking by means other than
hydrolysis or redox reactions. Such enzymes are particular in the sense that they only …

Recent progress in stereoselective synthesis with aldolases

P Clapés, WD Fessner, GA Sprenger… - Current Opinion in …, 2010 - Elsevier
Aldol reactions constitute a powerful methodology for carbon–carbon bond formation in
synthetic organic chemistry. Biocatalysis by means of aldolases offers a unique …

Systematic design and in vitro validation of novel one-carbon assimilation pathways

X Yang, Q Yuan, H Luo, F Li, Y Mao, X Zhao, J Du… - Metabolic …, 2019 - Elsevier
The utilization of one-carbon (C 1) assimilation pathways to produce chemicals and fuels
from low-cost C 1 compounds could greatly reduce the substrate-related production costs …

Recent advances in aldolase‐catalyzed asymmetric synthesis

SM Dean, WA Greenberg… - Advanced Synthesis & …, 2007 - Wiley Online Library
This review is focused on advances over the last several years in the application of
aldolases to organic synthesis. Several new technologies have been implemented to …

Biocatalytic Methods for C C Bond Formation

K Fesko, M Gruber‐Khadjawi - ChemCatChem, 2013 - Wiley Online Library
Carbon‐carbon bond formation is among the most challenging transformations in the
organic synthetic chemistry. Enzymes capable to perform this reaction are of great interest …

Current trends in asymmetric synthesis with aldolases

P Clapes, X Garrabou - Advanced Synthesis & Catalysis, 2011 - Wiley Online Library
Biocatalytic carbon‐carbon bond formation by means of aldolases offers an exceptionally
stereoselective and green tool for this strategic reaction in synthetic organic chemistry …