A framework for organizing cancer-related variations from existing databases, publications and NGS data using a High-performance Integrated Virtual Environment …
Years of sequence feature curation by UniProtKB/Swiss-Prot, PIR-PSD, NCBI-CDD, RefSeq
and other database biocurators has led to a rich repository of information on functional sites …
and other database biocurators has led to a rich repository of information on functional sites …
HIVE-hexagon: high-performance, parallelized sequence alignment for next-generation sequencing data analysis
L Santana-Quintero, H Dingerdissen, J Thierry-Mieg… - PloS one, 2014 - journals.plos.org
Due to the size of Next-Generation Sequencing data, the computational challenge of
sequence alignment has been vast. Inexact alignments can take up to 90% of total CPU time …
sequence alignment has been vast. Inexact alignments can take up to 90% of total CPU time …
Proteomic studies related to genetic determinants of variability in protein concentrations
Genetic variation has multiple effects on the proteome. It may influence the expression level
of proteins, modify their sequences through single nucleotide polymorphisms, the …
of proteins, modify their sequences through single nucleotide polymorphisms, the …
Structural and energetic analyses of SNPs in drug targets and implications for drug therapy
Mutations in drug targets can alter the therapeutic effects of drugs. Therefore, evaluating the
effects of single-nucleotide polymorphisms (SNPs) on drug-target binding is of significant …
effects of single-nucleotide polymorphisms (SNPs) on drug-target binding is of significant …
Human germline and pan-cancer variomes and their distinct functional profiles
Identification of non-synonymous single nucleotide variations (nsSNVs) has exponentially
increased due to advances in Next-Generation Sequencing technologies. The functional …
increased due to advances in Next-Generation Sequencing technologies. The functional …
Non-synonymous variations in cancer and their effects on the human proteome: workflow for NGS data biocuration and proteome-wide analysis of TCGA data
Background Next-generation sequencing (NGS) technologies have resulted in petabytes of
scattered data, decentralized in archives, databases and sometimes in isolated hard-disks …
scattered data, decentralized in archives, databases and sometimes in isolated hard-disks …
Differential expression of glycosyltransferases identified through comprehensive pan-cancer analysis
Despite accumulating evidence supporting a role for glycosylation in cancer progression
and prognosis, the complexity of the human glycome and glycoproteome poses many …
and prognosis, the complexity of the human glycome and glycoproteome poses many …
Predikce efektu bodových mutací na interakci proteinu s nukleovými kyselinami
VT Štěpánková - 2024 - dspace.cuni.cz
Bodové mutace jsou nejčastějším typem mutací a mnohé z nich mohou mít patogenní efekt,
je proto užitečné umět kvalitně a efektivně predikovat jejich vliv na daný protein, a právě …
je proto užitečné umět kvalitně a efektivně predikovat jejich vliv na daný protein, a právě …
[图书][B] Comprehensive Analysis of Glycosyltransferases in Cancer Identified from a Multifaceted Genomics Approach
HM Dingerdissen - 2021 - search.proquest.com
Despite accumulating evidence supporting a role for glycosylation in cancer progression
and prognosis, the complexity of the human glycome and study thereof poses many …
and prognosis, the complexity of the human glycome and study thereof poses many …
A framework for application of metabolic modeling in yeast to predict the effects of nsSNV in human orthologs
Background We have previously suggested a method for proteome wide analysis of
variation at functional residues wherein we identified the set of all human genes with …
variation at functional residues wherein we identified the set of all human genes with …