Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …

DJ-1 protein has multiple specific mechanisms to protect dopaminergic neurons against
neurodegeneration in Parkinson's disease. Wild type DJ-1 can acts as oxidative stress …

Neurons are critically dependent on mitochondrial integrity based on specific morphological,
biochemical, and physiological features. They are characterized by high rates of metabolic …

Chaperone-mediated autophagy (CMA) contributes to the lysosomal degradation of a
selective subset of proteins. Selectivity lies in the chaperone heat shock cognate 71 kDa …

Parkinson's disease (PD) is caused by dopaminergic neuronal death in the substantia nigra,
resulting in a reduced level of dopamine in the striatum. Oxidative stress and mitochondrial …

Advanced glycation end products (AGEs) are a heterogeneous group of molecules
produced, non‐enzymatically, from the interaction between reducing sugars and the free …

Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that
results primarily from the death of dopaminergic neurons in the substantia nigra. Although …

Loss-of-function DJ-1 mutations can cause early-onset Parkinson's disease. The function of
DJ-1 is unknown, but an acidic isoform accumulates after oxidative stress, leading to the …

Mitochondria are highly dynamic organelles which fulfill a plethora of functions. In addition to
their prominent role in energy metabolism, mitochondria are intimately involved in various …

Deletion and point (L166P) mutations of DJ‐1 have recently been shown to be responsible
for the onset of familial Parkinson's disease (PD, PARK7). The aim of this study was to …