Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by the full mutation as
well as highly localized methylation of the fragile X mental retardation 1 (FMR1) gene on the …

The metabotropic glutamate receptor 5 (mGluR5) is a key regulator of excitatory (E)
glutamate and inhibitory (I) γ-amino butyric acid (GABA) signalling in the brain. Despite the …

BACKGROUND FXLEARN, the first-ever large multisite trial of effects of disease-targeted
pharmacotherapy on learning, was designed to explore a paradigm for measuring effects of …

The involvement of the mGlu5 receptors in the pathophysiology of several forms of
monogenic autism has been supported by numerous studies following the seminal …

Multiple lines of evidence suggest that dysfunction of the metabotropic glutamate receptor
subtype 5 (mGluR5) plays a role in the pathogenesis of autism spectrum disorder (ASD). Yet …

Abstract Fragile X Syndrome (FXS) is a neurodevelopmental disorder caused by silencing of
the Fragile X Mental Retardation (FMR1) gene. The resulting loss of Fragile X Mental …

The metabotropic glutamate receptor subtype 5 (mGluR5) is a class C G-protein-coupled
receptor (GPCR) that has been implicated in various neuronal processes and, consequently …

Fragile X syndrome (FXS), the most common inherited cause of intellectual disability and the
single-gene cause of autism, is caused by decreased expression of the fragile X messenger …

Multiple lines of evidence suggest that a deficiency of Fragile X Mental Retardation Protein
(FMRP) mediates dysfunction of the metabotropic glutamate receptor subtype 5 (mGluR5) in …

Background: Fragile X syndrome (FXS), the most common single-gene cause of intellectual
disability and autism spectrum disorder (ASD), is caused by a> 200-trinucleotide repeat …