Alcoholic liver disease (ALD) is a globally prevalent chronic liver disease caused by chronic
or binge consumption of alcohol. The liver is the major organ that metabolizes alcohol; …

Extracellular vesicles (EVs) and particles (EPs) have recently emerged as active carriers of
molecular biomarkers and mediators of intercellular communication. While most …

Alcohol-related liver disease (ALD), which includes a range of disorders of different severity
and is one of the most prevalent types of liver disease worldwide, has recently regained …

Reactive aldehydes arise as by-products of metabolism and are normally cleared by
multiple families of enzymes. We find that mice lacking two aldehyde detoxifying enzymes …

Aims Aortic aneurysm/dissection (AAD) is a life-threatening disorder lacking effective
pharmacotherapeutic remedies. Aldehyde dehydrogenase 2 (ALDH2) polymorphism is tied …

A major mitochondrial enzyme for protecting cells from acetaldehyde toxicity is aldehyde
dehydrogenase 2 (ALDH2). The correlation between ALDH2 dysfunction and …

Intrahepatic neutrophil infiltration has been implicated in severe alcoholic hepatitis (SAH)
pathogenesis; however, the mechanism underlying neutrophil-induced injury in SAH …

Background and Aims Nonalcoholic fatty liver disease encompasses a spectrum of diseases
ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), cirrhosis, and liver …

Hepatocellular carcinoma (HCC) is one of the most common malignancies globally, and is
frequently associated with a poor prognosis. 5-methylcytosine (m 5 C) is a common …

Ethanol increases hepatic mitophagy driven by unknown mechanisms. Type 1 mitophagy
sequesters polarized mitochondria for nutrient recovery and cytoplasmic remodeling. In …