• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Aims/hypothesis The term prediabetes is used for individuals who have impaired glucose
metabolism whose glucose or HbA 1c levels are not yet high enough to be diagnosed as …

• The chronic hyperglycemia of diabetes is associated with significant longterm
microvascular and cardiovascular complications.• A fasting plasma glucose of≥ 7.0 mmol/L …

Summary 415 million people live with diabetes worldwide, and an estimated 193 million
people have undiagnosed diabetes. Type 2 diabetes accounts for more than 90% of patients …

Cardiovascular disease risk factor control as primary prevention in patients with type 2
diabetes mellitus has changed substantially in the past few years. The purpose of this …

ESC Guidelines 3039 administrative staff and by the referees and supervisory committees of
the two organizations. It is our hope that this huge effort has generated guidelines that will …

Over the past three decades, the number of people with diabetes mellitus has more than
doubled globally, making it one of the most important public health challenges to all nations …

Type 2 diabetes is now a pandemic and shows no signs of abatement. In this Seminar we
review the pathophysiology of this disorder, with particular attention to epidemiology …

Diabetic distal symmetric sensorimotor polyneuropathy (DSPN) represents a major health
problem, associated with excruciating neuropathic pain, increased morbidity and impaired …

Background HbA 1c is the standard measure by which to monitor long-term (2–3 months)
glucose control in people with diabetes and is now used for diagnosis of diabetes …