DNA replication is a complicated process that is largely regulated during stages of initiation.
The Siman Virus 40 in vitro replication system has served as an excellent model for studies …

Duplication of the simian virus 40 (SV40) genome is the best understood eukaryotic DNA
replication process to date. Like most prokaryotic genomes, the SV40 genome is a circular …

Abstract Chromatin assembly factor 1 (CAF-1) assembles nucleosomes in a replication-
dependent manner. The small subunit of CAF-1 (p48) is a member of a highly conserved …

Point mutations in the p53 gene are the most frequently identified genetic change in human
cancer. They convert murine p53 from a tumour suppressor gene into a dominant …

A cell free system that supports replication‐dependent chromatin assembly has been used
to determine the mechanism of histone deposition during DNA replication. CAF‐I, a human …

The mechanism by which transcription factors stimulate DNA replication in eukaryotes is
unknown. Bovine papillomavirus DNA synthesis requires the products of the viral E1 gene …

The identification and purification of human cell proteins required for the production of form I
DNA following DNA replication from the simian virus 40 (SV40) origin is described. Using …

Abstract Expression of the Epstein‐Barr virus (EBV) encoded nuclear antigens (EBNA 1 to 6)
and membrane‐associated protein (LMP) was investigated by immunoblotting in 83 …

A maximum-likelihood approach to multi-reference image refinement is presented. In
contrast to conventional cross-correlation refinement, the new approach includes a formal …

Plasmids containing the SV40 origin replicate in the presence of SV40 T antigen and a cell
free extract derived from human 293 cells. Upon fractionation of this extract, two essential …