Cancer metabolism is significantly altered from normal cellular metabolism allowing cancer
cells to adapt to changing microenvironments and maintain high rates of proliferation. In the …

The field of metabolic engineering is primarily concerned with improving the biological
production of value-added chemicals, fuels and pharmaceuticals through the design …

Precise quantification of metabolic pathway fluxes in biological systems is of major
importance in guiding efforts in metabolic engineering, biotechnology, microbiology, human …

Cancer metastasis accounts for the majority of cancer-related deaths and remains a clinical
challenge. Metastatic cancer cells generally resemble cells of the primary cancer, but they …

Methanol is a potentially attractive substrate for bioproduction of chemicals because of the
abundance of natural gas and biogas-derived methane. To move towards utilizing methanol …

Glucose and xylose are the two most abundant sugars derived from the breakdown of
lignocellulosic biomass. While aerobic glucose metabolism is relatively well understood in …

Highlights•Methanol is a cheap substrate for large-scale bioproduction of fuels and
chemicals.•Native methylotrophs are difficult to engineer and don't produce metabolites at …

In the era of sustainable development, the use of cell factories to produce various
compounds by fermentation has attracted extensive attention; however, industrial …

Synthetic methylotrophy aims to develop non-native methylotrophic microorganisms to
utilize methane or methanol to produce chemicals and biofuels. We report two …

Hyaluronic acid is a glycosaminoglycan biopolymer widely present throughout connective
and epithelial tissue, and has been of great interest for medical and cosmetic applications. In …