Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Background Acute blood loss in trauma requires quick identification and action to restore
circulating volume and save the patient. Massive transfusion protocols (MTPs) have become …

BACKGROUND There is a resurgence in the use of low‐titer group O whole blood (LTOWB)
for hemorrhagic shock. We hypothesized the use of LTOWB compared to component …

The transmembrane P-glycoprotein (P-gp) pumps that efflux drugs are a major mechanism
of cancer drug resistance. They are also important in protecting normal tissue cells from …

Objective: To compare a propensity-matched cohort of injured children receiving
conventional blood component transfusion to injured children receiving low-titer group O …

METHODS We performed a single-center, prospective, cluster randomized, prehospital
through in-hospital whole blood pilot trial for injured air medical patients. We compared …

OBJECTIVES: The purpose of our study was to describe children with life-threatening
bleeding. DESIGN: We conducted a prospective observational study of children with life …

A hemolytic transfusion reaction (HTR) is the accelerated clearance or destruction of red
blood cells associated with a transfusion event. Causes of HTRs and differential diagnoses …

BACKGROUND Whole blood (WB) has shown promise in pediatric trauma resuscitation
following its prominent role in the resuscitation of adult trauma patients. Although WB in …

Abstract Background Low‐titer Group O Whole Blood (LTOWB) is used with increasing
frequency in adult and pediatric trauma and massive bleeding transfusion protocols. There …