Chemical and biological evaluation of thiosemicarbazone-bearing heterocyclic metal complexes

AI Matesanz, JM Herrero… - Current topics in medicinal …, 2021 - ingentaconnect.com
Thiosemicarbazones (TSCNs) constitute a broad family of compounds (R1R2C= N-NH-C (S)-
NR3R4), particularly attractive because many of them display some biological activity …

Benzylpiperidine-linked diarylthiazoles as potential anti-Alzheimer's agents: synthesis and biological evaluation

M Shidore, J Machhi, K Shingala… - Journal of medicinal …, 2016 - ACS Publications
A novel series of hybrid molecules were designed and synthesized by fusing the
pharmacophoric features of cholinesterase inhibitor donepezil and diarylthiazole as …

[PDF][PDF] Synthesis of new thiazole and thiazolyl derivatives of medicinal significant-a short review

W Hussein, G Turan - MOJ Biorg. Org. Chem, 2018 - researchgate.net
In the field of therapeutic science, thiazoles are of extraordinary importance, because of their
potent and significant biological activities. Likewise thiazole and their derivatives are found …

Characterization of prodigiosin pigment by Serratia marcescens and the evaluation of its bioactivities

MT Koyun, S Sirin, B Aslim, G Taner, SN Dolanbay - Toxicology in Vitro, 2022 - Elsevier
The aim of the present study is to discover a bacterial pigment providing protection and
prevention of neurological damage and cancer development, which can have a role as a …

Design, synthesis, DFT, molecular docking, and biological evalution of pyrazole derivatives as potent acetyl cholinestrease inhibitors

HE Abdelwahab, HZ Ibrahim, AZ Omar - Journal of Molecular Structure, 2023 - Elsevier
Alzheimer's disease (AD) is an age-related chronic and progressive neurodegenerative
disease, affecting cognition, memory, and behavior. Treatment of Alzheimer's disease's (AD) …

Synthesis, Antioxidant and Some Enzyme Inhibition Activities of New Sulfonyl Hydrazones and their Molecular Docking Simulations

BSK Aktar, Y Sıcak, G Tatar, EE Oruç-Emre - Pharmaceutical Chemistry …, 2022 - Springer
In this work, a series of new sulfonyl hydrazones were synthesized and screened for
antioxidant and anticholinesterase, tyrosinase and urease enzyme inhibition activities. In …

Green and four-component cyclocondensation synthesis and in silico docking of new polyfunctionalized pyrrole derivatives as the potential anticholinesterase agents

MH Meshkatalsadat, A Mahmoudi, S Lotfi… - Molecular Diversity, 2022 - Springer
Synthesis of new substituted pyrrole scaffolds containing substituted thiadiazol-2-amine
moiety was successfully developed through one-pot and multi-component tandem …

In vitro anti-Helicobacter pylori, anti-urease and anti-gastric cancer activities of novel hydrazones

Z Maryam, B Kaya, HE Bostancı, D Kısa, İ Çelik… - Journal of Molecular …, 2024 - Elsevier
In this study, new hydrazone derivatives were synthesized by taking into account the
virulence factor of the urease in the urease-positive microorganism H. pylori. The structure of …

New 2-hydrazinothiazole derivatives as potential MAO-A, MAO-B, AChE, and BChE inhibitors

B Tutuş, AE Evren, BN Sağlik Özkan… - Phosphorus, Sulfur, and …, 2024 - Taylor & Francis
The incidence of neurodegenerative Alzheimer's and Parkinson's diseases is increasing
worldwide every day, and treatment options are currently very limited. There is no definitive …

Evaluation of phenolic profile, antioxidant and anticholinesterase effects of Fuscoporia torulosa

ME Duru, TELÇ Gülsen, E Deveci - International Journal of …, 2019 - dergipark.org.tr
In this study, we investigated antioxidant and anticholinesterase activities of the hexane,
chloroform, acetone, methanol and water extracts of F. torulosa mushroom with total …