Heart disease is one of the major life-threatening diseases with high mortality and incidence
worldwide. Several model systems, such as primary cells and animals, have been used to …

Engineered human cardiac tissues have been utilized for various biomedical applications,
including drug testing, disease modeling, and regenerative medicine. However, the …

Direct cardiac reprogramming has emerged as a promising therapeutic approach for cardiac
regeneration. Full chemical reprogramming with small molecules to generate …

Cardiac microphysiological systems are accurate in vitro platforms that reveal the biological
mechanisms underlying cardiopathy, accelerating pharmaceutical research in this field …

Organotypic micrometre-size 3D aggregates of skin cells (multicellular spheroids) have
emerged as a promising in vitro model that can be utilized as an alternative of animal …

In this paper, we report the development of a wireless, passive, biocompatible, and flexible
system for stimulation of human induced pluripotent stem cell derived cardiomyocytes …

Pluripotent and direct reprogramming technologies hold great potential for tissue repair and
restoration of tissue and organ function. The implementation of induced pluripotent stem …

This paper describes an electrical stimulation system for maturing microfiber‐shaped
cardiac tissue (cardiac microfibers, CMFs). The system enables stable culturing of CMFs …

Heart degenerative diseases pose a significant challenge due to the limited ability of native
heart to restore lost cardiomyocytes. Direct cellular reprogramming technology, particularly …

As research on in vitro cardiotoxicity assessment and cardiac disease modeling becomes
more important, the demand for human pluripotent stem cell-derived cardiomyocytes (hPSC …