Pulmonary arterial hypertension (PAH) is a rare dyspnoea-fatigue syndrome caused by a
progressive increase in pulmonary vascular resistance and eventual right ventricular (RV) …

Background Some patients with COVID-19 who have recovered from the acute infection
after experiencing only mild symptoms continue to exhibit persistent exertional limitation that …

Right ventricular–pulmonary artery coupling (RV-PA coupling) refers to the relationship
between RV contractility and RV afterload. Normal RV-PA coupling is maintained only when …

Heart failure with preserved ejection fraction (HFpEF) patients have an increased ventilatory
demand. Whether their ventilatory capacity can meet this increased demand is unknown …

Right ventricular (RV) functional adaptation to afterload determines outcome in pulmonary
hypertension (PH). RV afterload is determined by the dynamic interaction between …

Right heart (RH) failure carries a high rate of morbidity and mortality. Patients who present
with RH failure often exhibit complex aberrant cardio-pulmonary physiology with varying …

Aims To explore the effects of age and sex in adolescents vs. young or middle-aged adults
on pulmonary vascular function and right ventricular-arterial (RV-PA) coupling as assessed …

Mitochondria are important organelles that act as a primary site to produce reactive oxygen
species (ROS). Additionally, mitochondria play a pivotal role in the regulation of Ca2+ …

Pulmonary hypertension (PH) in interstitial lung disease (ILD) is associated with increased
mortality and impaired exertional capacity. Right heart catheterization is the diagnostic …

Background Pulmonary vascular distensibility associates with right ventricular function and
clinical outcomes in patients with unexplained dyspnea and pulmonary hypertension. Alpha …