Skeletal muscle requires a highly orchestrated coordination between multiple cell types and
their microenvironment to exert its function and to maintain its homeostasis and regenerative …

Highlights•Numerous pathophysiological features of DMD provide different therapeutic
avenues.•Pharmacolougical therapies target all muscles and are applicable to all DMD …

The thrombospondin (Thbs) family of secreted matricellular proteins are stress-and injury-
induced mediators of cellular attachment dynamics and extracellular matrix protein …

Skeletal muscle stem and progenitor cells including those derived from human pluripotent
stem cells (hPSCs) offer an avenue towards personalized therapies and readily fuse to form …

Duchenne muscular dystrophy (DMD) is a devastating disease featuring skeletal muscle
wasting, respiratory insufficiency, and cardiomyopathy. Historically, respiratory failure has …

Cardiac fibrosis is a common pathologic consequence of stress insult to the heart and is
characterized by abnormal deposition of fibrotic extracellular matrix that compromises …

The mitochondrial Ca 2+ uniporter (MCU) complex mediates acute mitochondrial Ca 2+
influx. In skeletal muscle, MCU links Ca 2+ signaling to energy production by directly …

A defining characteristic of pulmonary hypertension (PH) is the extensive remodeling of
pulmonary arteries (PAs), which results in progressive increases in vascular resistance and …

The progressive degeneration of the skeletal musculature in Duchenne muscular dystrophy
is accompanied by reactive myofibrosis, fat substitution, and chronic inflammation. Fibrotic …

Abstract Thrombospondin-4 (TSP-4) belongs to the thrombospondin protein family that
consists of five highly homologous members. A number of novel functions have been …