Dexosomes as a cell-free vaccine for cancer immunotherapy

S Nikfarjam, J Rezaie, F Kashanchi, R Jafari - Journal of Experimental & …, 2020 - Springer
Dendritic cells (DCs) secrete vast quantities of exosomes termed as dexosomes.
Dexosomes are symmetric nanoscale heat-stable vesicles that consist of a lipid bilayer …

Structural basis of integrin regulation and signaling

BH Luo, CV Carman, TA Springer - Annu. Rev. Immunol., 2007 - annualreviews.org
Integrins are cell adhesion molecules that mediate cell-cell, cell–extracellular matrix, and
cell-pathogen interactions. They play critical roles for the immune system in leukocyte …

Material stiffness influences the polarization state, function and migration mode of macrophages

R Sridharan, B Cavanagh, AR Cameron, DJ Kelly… - Acta biomaterialia, 2019 - Elsevier
Biomaterial implantation is followed by an inflammatory cascade dominated by
macrophages, which determine implant acceptance or rejection through pro-and anti …

ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer

R Taftaf, X Liu, S Singh, Y Jia, NK Dashzeveg… - Nature …, 2021 - nature.com
Circulating tumor cell (CTC) clusters mediate metastasis at a higher efficiency and are
associated with lower overall survival in breast cancer compared to single cells. Combining …

Functions of hyaluronan in wound repair

WYJ Chen - Hyaluronan, 2002 - Elsevier
Hyaluronan (HA), a major extracellular matrix macromolecule, has a repeated disaccharide
structure that is completely conserved throughout a large span of evolution, indicating a …

Neutrophils in innate host defense against Staphylococcus aureus infections

KM Rigby, FR DeLeo - Seminars in immunopathology, 2012 - Springer
Staphylococcus aureus has been an important human pathogen throughout history and is
currently a leading cause of bacterial infections worldwide. S. aureus has the unique ability …

T‐cell‐mimicking nanoparticles for cancer immunotherapy

M Kang, J Hong, M Jung, SP Kwon, SY Song… - Advanced …, 2020 - Wiley Online Library
Cancer immunotherapies, including adoptive T cell transfer and immune checkpoint
blockades, have recently shown considerable success in cancer treatment. Nevertheless …

Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins

MB Lawrence, TA Springer - Cell, 1991 - cell.com
Rolling of leukocytes on vascular endotheliai cells, an early event in inflammation, can be
reproduced in vitro on artificial lipid bilayers containing purified CD62, a seiectln also named …

Neutrophils Versus Staphylococcus aureus: A Biological Tug of War

AN Spaan, BGJ Surewaard, R Nijland… - Annual review of …, 2013 - annualreviews.org
The pathogen Staphylococcus aureus is well adapted to its human host. Neutrophil-
mediated killing is a crucial defense system against S. aureus; however, the pathogen has …

Phagocytosis and the actin cytoskeleton

RC May, LM Machesky - Journal of cell science, 2001 - journals.biologists.com
The process of engulfing a foreign particle–phagocytosis–is of fundamental importance for a
wide diversity of organisms. From simple unicellular organisms that use phagocytosis to …