Dexosomes as a cell-free vaccine for cancer immunotherapy
Dendritic cells (DCs) secrete vast quantities of exosomes termed as dexosomes.
Dexosomes are symmetric nanoscale heat-stable vesicles that consist of a lipid bilayer …
Dexosomes are symmetric nanoscale heat-stable vesicles that consist of a lipid bilayer …
Structural basis of integrin regulation and signaling
BH Luo, CV Carman, TA Springer - Annu. Rev. Immunol., 2007 - annualreviews.org
Integrins are cell adhesion molecules that mediate cell-cell, cell–extracellular matrix, and
cell-pathogen interactions. They play critical roles for the immune system in leukocyte …
cell-pathogen interactions. They play critical roles for the immune system in leukocyte …
Material stiffness influences the polarization state, function and migration mode of macrophages
Biomaterial implantation is followed by an inflammatory cascade dominated by
macrophages, which determine implant acceptance or rejection through pro-and anti …
macrophages, which determine implant acceptance or rejection through pro-and anti …
ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer
R Taftaf, X Liu, S Singh, Y Jia, NK Dashzeveg… - Nature …, 2021 - nature.com
Circulating tumor cell (CTC) clusters mediate metastasis at a higher efficiency and are
associated with lower overall survival in breast cancer compared to single cells. Combining …
associated with lower overall survival in breast cancer compared to single cells. Combining …
Functions of hyaluronan in wound repair
WYJ Chen - Hyaluronan, 2002 - Elsevier
Hyaluronan (HA), a major extracellular matrix macromolecule, has a repeated disaccharide
structure that is completely conserved throughout a large span of evolution, indicating a …
structure that is completely conserved throughout a large span of evolution, indicating a …
Neutrophils in innate host defense against Staphylococcus aureus infections
KM Rigby, FR DeLeo - Seminars in immunopathology, 2012 - Springer
Staphylococcus aureus has been an important human pathogen throughout history and is
currently a leading cause of bacterial infections worldwide. S. aureus has the unique ability …
currently a leading cause of bacterial infections worldwide. S. aureus has the unique ability …
T‐cell‐mimicking nanoparticles for cancer immunotherapy
Cancer immunotherapies, including adoptive T cell transfer and immune checkpoint
blockades, have recently shown considerable success in cancer treatment. Nevertheless …
blockades, have recently shown considerable success in cancer treatment. Nevertheless …
Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins
MB Lawrence, TA Springer - Cell, 1991 - cell.com
Rolling of leukocytes on vascular endotheliai cells, an early event in inflammation, can be
reproduced in vitro on artificial lipid bilayers containing purified CD62, a seiectln also named …
reproduced in vitro on artificial lipid bilayers containing purified CD62, a seiectln also named …
Neutrophils Versus Staphylococcus aureus: A Biological Tug of War
AN Spaan, BGJ Surewaard, R Nijland… - Annual review of …, 2013 - annualreviews.org
The pathogen Staphylococcus aureus is well adapted to its human host. Neutrophil-
mediated killing is a crucial defense system against S. aureus; however, the pathogen has …
mediated killing is a crucial defense system against S. aureus; however, the pathogen has …
Phagocytosis and the actin cytoskeleton
RC May, LM Machesky - Journal of cell science, 2001 - journals.biologists.com
The process of engulfing a foreign particle–phagocytosis–is of fundamental importance for a
wide diversity of organisms. From simple unicellular organisms that use phagocytosis to …
wide diversity of organisms. From simple unicellular organisms that use phagocytosis to …