The pharmacology of neurotrophic treatment with Cerebrolysin: brain protection and repair to counteract pathologies of acute and chronic neurological disorders.

E Masliah, E Diez-Tejedor - Drugs of today (Barcelona, Spain: 1998 …, 2012 - europepmc.org
Neurotrophic factors are considered as part of the therapeutic strategy for neurological
disorders like dementia, stroke and traumatic brain injury. Cerebrolysin is a neuropeptide …

Cerebrolysin in the therapy of mild cognitive impairment and dementia due to Alzheimer's disease: 30 years of clinical use

SI Gavrilova, A Alvarez - Medicinal Research Reviews, 2021 - Wiley Online Library
Alzheimer's disease (AD) is the most common neurocognitive disorder and a global health
problem. The prevalence of AD is growing dramatically, especially in low‐and middle …

Antiapoptotic effects of the peptidergic drug cerebrolysin on primary cultures of embryonic chick cortical neurons

M Hartbauer, B Hutter-Paier, G Skofitsch… - Journal of neural …, 2001 - Springer
Cerebrolysin (EBEWE Arzneimittel, Austria, Europe) is a widely used drug relieving the
symptoms of a variety of neurological disorders, particularly of neurodegenerative dementia …

Effects of Cerebrolysin™ on neurogenesis in an APP transgenic model of Alzheimer's disease

E Rockenstein, M Mante, A Adame, L Crews… - Acta …, 2007 - Springer
Cerebrolysin (CBL) is a peptide mixture with neurotrophic effects that might reduce the
neurodegenerative alterations in Alzheimer's disease (AD). We have previously shown that …

Cerebrolysin decreases amyloid‐β production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease

E Rockenstein, M Torrance, M Mante… - Journal of …, 2006 - Wiley Online Library
Cerebrolysin is a peptide mixture with neurotrophic effects that might reduce the
neurodegenerative pathology in Alzheimer's disease (AD). We have previously shown in an …

Expression and functions of fibroblast growth factor 2 (FGF-2) in hippocampal formation

S Zechel, S Werner, K Unsicker… - The …, 2010 - journals.sagepub.com
Among the 23 members of the fibroblast growth factor (FGF) family, FGF-2 is the most
abundant one in the central nervous system. Its impact on neural cells has been profoundly …

Cerebrolysin modulates pronerve growth factor/nerve growth factor ratio and ameliorates the cholinergic deficit in a transgenic model of Alzheimer's disease

K Ubhi, E Rockenstein… - Journal of …, 2013 - Wiley Online Library
Alzheimer's disease (AD) is characterized by degeneration of neocortex, limbic system, and
basal forebrain, accompanied by accumulation of amyloid‐β and tangle formation …

Alzheimer's disease: recent advances and future perspectives

K Ubhi, E Masliah - Journal of Alzheimer's disease, 2012 - journals.sagepub.com
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by
progressive memory deficits and other cognitive disturbances. Neuropathologically, AD is …

Apoptosis modulators in the therapy of neurodegenerative diseases

HP Deigner, U Haberkorn… - Expert opinion on …, 2000 - Taylor & Francis
Apoptosis is a prerequisite to model the developing nervous system. However, an increased
rate of cell death in the adult nervous system underlies neurodegenerative disease and is a …

Effects of reactive oxygen and nitrogen species on TrkA expression and signalling: implications for proNGF in aging and Alzheimer's disease

E Kropf, M Fahnestock - Cells, 2021 - mdpi.com
Nerve growth factor (NGF) and its precursor form, proNGF, are critical for neuronal survival
and cognitive function. In the brain, proNGF is the only detectable form of NGF …