Biological targets, such as proteins and nucleic acids, are chiral, therefore stereoisomers of
chiral molecules interact with these targets differently and, indeed, the antitumor drug …

We report the preparation of selenium‐containing platinum‐based anticancer drug EG‐
Se/Pt. EG‐Se/Pt was obtained from the coordination of selenium‐containing molecules (EG …

DNA molecules have come under the spotlight as potential templates for the fabrication of
nanoscale products, such as molecular‐scale electronic or photonic devices. Herein, we …

This chapter, divided into three sections, reviews the literature reported during 2010 in the
field of interaction of metal complexes with nucleic acids and complex formation between …

Oxaliplatin and cisplatin belong to the class of platinum‐based anticancer agents. Formation
of DNA adducts by these complexes and the consequences for its structure and function, is …

1.1. 1 DNA platination. PtII and PtIV complexes. Platination (in reference to the formation of a
covalent bond between nucleic acids and a platinum centre) is generally understood to …

Cisplatin (cis-[PtCl2 (NH3) 2]), one of the most potent antitumor drugs currently in clinical
use, is known to target DNA by forming bifunctional adducts [1]. Ancillary ligands can …

12. BEZEMER TM, FOUNTAIN MT, BAREA JM, CHRISTENSEN S., DEKKER SC, DUYTS H.,
VAN HAL R., HARVEY JA, HEDLUND K., MARAUN M., MIKOLA J., MLADENOV AG, ROBIN …