Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Protein palmitoylation, a classical and common lipid modification, regulates diverse aspects
of neuronal protein trafficking and function. The reversible nature of palmitoylation provides …

Phosphoinositides are lipids that are present in the cytoplasmic leaflet of a cell's plasma and
internal membranes and play pivotal roles in the regulation of a wide variety of cellular …

Abstract The phosphatidylinositol 4-kinases (PI4Ks) synthesize phosphatidylinositol 4-
phosphate (PI4P), a key member of the phosphoinositide family. PI4P defines the …

Lipid phosphoinositides are master signaling molecules in eukaryotic cells and key markers
of organelle identity. Because of these important roles, the kinases and phosphatases that …

Several RNA viruses have recently been shown to hijack members of the host
phosphatidylinositol (PtdIns) 4-kinase (PI4K) family of enzymes. They use PI4K to generate …

Initially identified as a key phosphoinositide that controls membrane trafficking at the Golgi
complex, phosphatidylinositol‐4‐phosphate (PI4P) has emerged as a key molecule in the …

Plasma membrane (PM) phosphatidylinositol 4, 5-bisphosphate [PI (4, 5) P2] regulates the
activity of many ion channels and other membrane-associated proteins. To determine …

Regulated secretion is a fundamental cellular process in which biologically active molecules
stored in long-lasting secretory granules (SGs) are secreted in response to external stimuli …

Phosphatidylinositol lipids are signaling molecules involved in nearly all aspects of cellular
regulation. Production of phosphatidylinositol 4-phosphate (PI4P) has long been recognized …