Ferroptosis is a recently identified, iron-regulated, non-apoptotic form of cell death. It is
characterized by cellular accumulation of lipid reactive oxygen species that ultimately leads …

ATF4 is a cellular stress induced bZIP transcription factor that is a hallmark effector of the
integrated stress response. The integrated stress response is triggered by phosphorylation …

Abstract System xc− was recently described as the most upstream node in a novel form of
regulated necrotic cell death, called ferroptosis. In this context, the small molecule erastin …

Although nerve cell death is the hallmark of many neurological diseases, the processes
underlying this death are still poorly defined. However, there is a general consensus that …

Cancer cells exhibit an abnormal amino acid metabolism and a dependence on specific
amino acids, which might provide potential targets for treating cancer patients. In this study …

Molecular, genetic and pathological evidence suggests that deficits in GABAergic
parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through …

The human brain generally remains structurally and functionally sound for many decades,
despite the post-mitotic and non-regenerative nature of neurons. This is testament to the …

The astrocytic glutamate transporters excitatory amino acid transporters 1 and 2 (EAAT1 and
EAAT2) play a key role in nervous system function to maintain extracellular glutamate levels …

The protein kinase Gcn2 is present in virtually all eukaryotes and is of increasing interest
due to its involvement in a large array of crucial biological processes. Some of these are …

This review provides an overview of the biochemistry of thiol redox couples and the
significance of thiol redox homeostasis in neurodegenerative disease. The discussion is …