[HTML][HTML] Parkinson's disease: animal models and dopaminergic cell vulnerability

J Blesa, S Przedborski - Frontiers in neuroanatomy, 2014 - frontiersin.org
Parkinson's disease (PD) is a neurodegenerative disorder that affects about 1.5% of the
global population over 65 years of age. A hallmark feature of PD is the degeneration of the …

Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms

R Moratalla, A Khairnar, N Simola, N Granado… - Progress in …, 2017 - Elsevier
Amphetamine-related drugs, such as 3, 4-methylenedioxymethamphetamine (MDMA) and
methamphetamine (METH), are popular recreational psychostimulants. Several preclinical …

Neurotoxicity of MDMA: main effects and mechanisms

G Costa, K Gołembiowska - Experimental neurology, 2022 - Elsevier
Preclinical and clinical studies indicate that 3, 4-methylenedioxymethamphetamine
(MDMA;'ecstasy'), in addition to having abuse potential, may elicit acute and persistent …

Animal models of Parkinson's disease: An updated overview

P Gubellini, P Kachidian - Revue neurologique, 2015 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder whose etiology,
besides a minority of genetic cases, is still largely unknown. Animal models have contributed …

Dynamic changes in the nigrostriatal pathway in the MPTP mouse model of Parkinson's disease

D Huang, J Xu, J Wang, J Tong, X Bai, H Li… - Parkinson's …, 2017 - Wiley Online Library
The characteristic brain pathology and motor and nonmotor symptoms of Parkinson's
disease (PD) are well established. However, the details regarding the causes of the disease …

[HTML][HTML] Suppression of abnormal α-synuclein expression by activation of BDNF transcription ameliorates Parkinson's disease-like pathology

Q Cao, S Luo, W Yao, Y Qu, N Wang, J Hong… - … Therapy-Nucleic Acids, 2022 - cell.com
Parkinson's disease (PD) is characterized by the formation of Lewy bodies (LBs) in the brain.
LBs are mainly composed of phosphorylated and aggregated α-synuclein (α-Syn). Thus …

Inhibition of abnormal C/EBPβ/α‐Syn signaling pathway through activation of Nrf2 ameliorates Parkinson's disease‐like pathology

Z Lin, L Huang, Q Cao, H Luo, W Yao, J Zhang - Aging Cell, 2023 - Wiley Online Library
Parkinson's disease (PD) is characterized by the formation of Lewy bodies (LBs) in the brain.
These LBs are primarily composed of α‐Synuclein (α‐Syn), which has aggregated. A recent …

[HTML][HTML] Characterization of Nasco grape pomace-loaded nutriosomes and their neuroprotective effects in the MPTP mouse model of Parkinson's disease

P Parekh, M Serra, M Allaw, M Perra… - Frontiers in …, 2022 - frontiersin.org
Grape pomaces have recently received great attention for their richness in polyphenols,
compounds known to exert anti-inflammatory and antioxidant effects. These pomaces …

Classic and evolving animal models in Parkinson's disease

T Pingale, GL Gupta - Pharmacology Biochemistry and Behavior, 2020 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disease with motor and non-
motor symptoms. PD is characterized by the degeneration of dopaminergic neurons in the …

[HTML][HTML] Neonatal chlorpyrifos exposure induces loss of dopaminergic neurons in young adult rats

J Zhang, H Dai, Y Deng, J Tian, C Zhang, Z Hu, G Bing… - Toxicology, 2015 - Elsevier
Increasing epidemiological and toxicological evidence suggests that pesticides and other
environmental exposures may be associated with the development of Parkinson's disease …