[HTML][HTML] Parkinson's disease: animal models and dopaminergic cell vulnerability
J Blesa, S Przedborski - Frontiers in neuroanatomy, 2014 - frontiersin.org
Parkinson's disease (PD) is a neurodegenerative disorder that affects about 1.5% of the
global population over 65 years of age. A hallmark feature of PD is the degeneration of the …
global population over 65 years of age. A hallmark feature of PD is the degeneration of the …
Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms
Amphetamine-related drugs, such as 3, 4-methylenedioxymethamphetamine (MDMA) and
methamphetamine (METH), are popular recreational psychostimulants. Several preclinical …
methamphetamine (METH), are popular recreational psychostimulants. Several preclinical …
Neurotoxicity of MDMA: main effects and mechanisms
G Costa, K Gołembiowska - Experimental neurology, 2022 - Elsevier
Preclinical and clinical studies indicate that 3, 4-methylenedioxymethamphetamine
(MDMA;'ecstasy'), in addition to having abuse potential, may elicit acute and persistent …
(MDMA;'ecstasy'), in addition to having abuse potential, may elicit acute and persistent …
Animal models of Parkinson's disease: An updated overview
P Gubellini, P Kachidian - Revue neurologique, 2015 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder whose etiology,
besides a minority of genetic cases, is still largely unknown. Animal models have contributed …
besides a minority of genetic cases, is still largely unknown. Animal models have contributed …
Dynamic changes in the nigrostriatal pathway in the MPTP mouse model of Parkinson's disease
D Huang, J Xu, J Wang, J Tong, X Bai, H Li… - Parkinson's …, 2017 - Wiley Online Library
The characteristic brain pathology and motor and nonmotor symptoms of Parkinson's
disease (PD) are well established. However, the details regarding the causes of the disease …
disease (PD) are well established. However, the details regarding the causes of the disease …
[HTML][HTML] Suppression of abnormal α-synuclein expression by activation of BDNF transcription ameliorates Parkinson's disease-like pathology
Q Cao, S Luo, W Yao, Y Qu, N Wang, J Hong… - … Therapy-Nucleic Acids, 2022 - cell.com
Parkinson's disease (PD) is characterized by the formation of Lewy bodies (LBs) in the brain.
LBs are mainly composed of phosphorylated and aggregated α-synuclein (α-Syn). Thus …
LBs are mainly composed of phosphorylated and aggregated α-synuclein (α-Syn). Thus …
Inhibition of abnormal C/EBPβ/α‐Syn signaling pathway through activation of Nrf2 ameliorates Parkinson's disease‐like pathology
Z Lin, L Huang, Q Cao, H Luo, W Yao, J Zhang - Aging Cell, 2023 - Wiley Online Library
Parkinson's disease (PD) is characterized by the formation of Lewy bodies (LBs) in the brain.
These LBs are primarily composed of α‐Synuclein (α‐Syn), which has aggregated. A recent …
These LBs are primarily composed of α‐Synuclein (α‐Syn), which has aggregated. A recent …
[HTML][HTML] Characterization of Nasco grape pomace-loaded nutriosomes and their neuroprotective effects in the MPTP mouse model of Parkinson's disease
Grape pomaces have recently received great attention for their richness in polyphenols,
compounds known to exert anti-inflammatory and antioxidant effects. These pomaces …
compounds known to exert anti-inflammatory and antioxidant effects. These pomaces …
Classic and evolving animal models in Parkinson's disease
Parkinson's disease (PD) is a progressive neurodegenerative disease with motor and non-
motor symptoms. PD is characterized by the degeneration of dopaminergic neurons in the …
motor symptoms. PD is characterized by the degeneration of dopaminergic neurons in the …
[HTML][HTML] Neonatal chlorpyrifos exposure induces loss of dopaminergic neurons in young adult rats
Increasing epidemiological and toxicological evidence suggests that pesticides and other
environmental exposures may be associated with the development of Parkinson's disease …
environmental exposures may be associated with the development of Parkinson's disease …