Cancer is a problem with worldwide importance and is the second leading cause of death
globally. Cancer cells reprogram their metabolism to support their uncontrolled expansion …

Polyphenolic flavonoids are considered natural, non-toxic chemopreventers, which are most
commonly derived from plants, fruits, and vegetables. Most of these polyphenolics exhibit …

Animal experiments remain essential to understand the fundamental mechanisms
underpinning malignancy and to discover improved methods to prevent, diagnose and treat …

The Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating a
wide array of genes for antioxidant and detoxification enzymes in response to oxidative and …

Methylated flavonoids are an important type of natural flavonoid derivative with potentially
multiple health benefits; among other things, they have improved bioavailability compared …

Polyphenols have been reported to have wide spectrum of biological activities including
major impact on initiation, promotion, and progression of cancer by modulating different …

Our understanding of the structure and biosynthetic pathway of lignin, a phenylpropanoid
heteropolymer, continues to evolve, especially with the discovery of new lignin …

Apigenin (4′, 5, 7‐trihydroxyflavone, 5, 7‐dihydroxy‐2‐(4‐hydroxyphenyl)‐4H‐1‐
benzopyran‐4‐one) is a flavonoid found in many fruits, vegetables, and herbs, the most …

Tricin (3', 5'-dimethoxyflavone) is a specialized metabolite which not only confers stress
tolerance and involves in defense responses in plants but also represents a promising …

Flavonoids comprise a group of natural polyphenols consisting of more than 5,000 subtypes
mostly existing in fruits and vegetables. Flavonoids consumption could potentially attenuate …