Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

In recent years views of eukaryotic gene expression have been transformed by the finding
that enormous diversity can be generated at the RNA level. Advances in technologies for …

Alternative splicing has a crucial role in the generation of biological complexity, and its
misregulation is often involved in human disease. Here we describe the assembly of a …

From a large-scale screen using splicing microarrays and RT-PCR, we identified 63
alternative splicing (AS) events that are coordinated in 3 distinct temporal patterns during …

Alternative splicing of pre-mRNA increases the diversity of protein functions. Here we show
that about half of all active alternative splicing events in ovarian and breast tissues are …

Alternative pre–messenger RNA splicing influences development, physiology and disease,
but its regulation in humans is not well understood, partially because of the limited scale at …

The paraneoplastic neurologic disorders target several families of neuron-specific RNA
binding proteins (RNABPs), revealing that there are unique aspects of gene expression …

The precise regulation of many alternative splicing (AS) events by specific splicing factors is
essential to determine tissue types and developmental stages. However, the molecular …

The Rbfox genes encode an ancient family of sequence‐specific RNA binding proteins
(RBPs) that are critical developmental regulators in multiple tissues including skeletal …

Alternative splicing contributes to muscle development, but a complete set of muscle-
splicing factors and their combinatorial interactions are unknown. Previous work identified …