Hereditary angioedema
PJ Busse, SC Christiansen - New England Journal of Medicine, 2020 - Mass Medical Soc
Hereditary Angioedema Hereditary angioedema is a rare genetic disease that may include
recurrent attacks of cutaneous angioedema, severe abdominal pain, and airway …
recurrent attacks of cutaneous angioedema, severe abdominal pain, and airway …
Differences and similarities in the mechanisms and clinical expression of bradykinin-mediated vs. mast cell–mediated angioedema
Angioedema (AE), transient localized swelling due to extravasated fluid, is commonly
classified as mast cell mediator-induced, bradykinin-mediated or of unknown cause. AE …
classified as mast cell mediator-induced, bradykinin-mediated or of unknown cause. AE …
[HTML][HTML] The international WAO/EAACI guideline for the management of hereditary angioedema–the 2021 revision and update
Hereditary Angioedema (HAE) is a rare and disabling disease for which early diagnosis and
effective therapy are critical. This revision and update of the global WAO/EAACI guideline on …
effective therapy are critical. This revision and update of the global WAO/EAACI guideline on …
The international WAO/EAACI guideline for the management of hereditary angioedema–the 2017 revision and update
Hereditary Angioedema (HAE) is a rare and disabling disease. Early diagnosis and
appropriate therapy are essential. This update and revision of the global guideline for HAE …
appropriate therapy are essential. This update and revision of the global guideline for HAE …
International consensus on the diagnosis and management of pediatric patients with hereditary angioedema with C1 inhibitor deficiency
H Farkas, I Martinez‐Saguer, K Bork, T Bowen… - Allergy, 2017 - Wiley Online Library
Background The consensus documents published to date on hereditary angioedema with
C1 inhibitor deficiency (C1‐INH‐HAE) have focused on adult patients. Many of the previous …
C1 inhibitor deficiency (C1‐INH‐HAE) have focused on adult patients. Many of the previous …
Prophylactic use of an anti-activated factor XII monoclonal antibody, garadacimab, for patients with C1-esterase inhibitor-deficient hereditary angioedema: a …
Background Hereditary angioedema is associated with dysregulation of the kallikrein–kinin
system. Factor XII (FXII) is a key initiator of the kallikrein–kinin system, which produces …
system. Factor XII (FXII) is a key initiator of the kallikrein–kinin system, which produces …
HAE pathophysiology and underlying mechanisms
BL Zuraw, SC Christiansen - Clinical reviews in allergy & immunology, 2016 - Springer
Remarkable progress in understanding the pathophysiology and underlying mechanisms of
hereditary angioedema has led to the development of effective treatment for this disorder …
hereditary angioedema has led to the development of effective treatment for this disorder …
[HTML][HTML] Hereditary angioedema: the plasma contact system out of control
The plasma contact system contributes to thrombosis in experimental models. Even though
our standard blood coagulation tests are prolonged when plasma lacks contact factors, this …
our standard blood coagulation tests are prolonged when plasma lacks contact factors, this …
Multiple roles of complement MASP-1 at the interface of innate immune response and coagulation
J Dobó, V Schroeder, L Jenny, L Cervenak… - Molecular …, 2014 - Elsevier
MASP-1 is a versatile serine protease that cleaves a number of substrates in human blood.
In recent years it became evident that besides playing a crucial role in complement …
In recent years it became evident that besides playing a crucial role in complement …
Plasminflammation—an emerging pathway to bradykinin production
C Maas - Frontiers in Immunology, 2019 - frontiersin.org
Plasminogen activation is essential for fibrinolysis—the breakdown of fibrin polymers in
blood clots. Besides this important function, plasminogen activation participates in a wide …
blood clots. Besides this important function, plasminogen activation participates in a wide …