Iron is an essential micronutrient, and, in the case of bacteria, its availability is commonly a
growth-limiting factor. However, correct functioning of cells requires that the labile pool of …

Strains of Clostridioides difficile cause detrimental diarrheas with thousands of deaths
worldwide. The infection process by the Gram-positive, strictly anaerobic gut bacterium is …

Clostridioides difficile infection (CDI) remains an urgent global One Health threat. The
genetic heterogeneity seen across C. difficile underscores its wide ecological versatility and …

Leveraging systems biology approaches, we illustrate how metabolically distinct species of
Clostridia protect against or worsen Clostridioides difficile infection in mice by modulating …

Clostridioides difficile is a pathogenic bacterium that infects the human colon to cause
diarrheal disease. Growth of the bacterium is known to be dependent on certain bile acids …

Clostridia comprise bacteria of environmental, biotechnological and medical interest and
many commensals of the gut microbiota. Because of their strictly anaerobic lifestyle, oxygen …

The gram-positive human pathogen Clostridioides difficile has emerged as the leading
cause of antibiotic-associated diarrhea. However, little is known about the bacterium's …

Iron is an essential element for almost all living organisms, but can be extremely toxic in high
concentrations. All organisms must therefore employ homeostatic mechanisms to finely …

Much of our current knowledge about cellular RNA–protein complexes in bacteria is derived
from analyses in gram-negative model organisms, with the discovery of RNA-binding …

Clostridioides difficile is a leading cause of antibiotic-associated diarrheal disease. C.
difficile colonization, growth, and toxin production in the intestine is strongly associated with …