[HTML][HTML] Bacterial iron detoxification at the molecular level
JM Bradley, DA Svistunenko, MT Wilson… - Journal of Biological …, 2020 - ASBMB
Iron is an essential micronutrient, and, in the case of bacteria, its availability is commonly a
growth-limiting factor. However, correct functioning of cells requires that the labile pool of …
growth-limiting factor. However, correct functioning of cells requires that the labile pool of …
[HTML][HTML] Metabolism the Difficile Way: The Key to the Success of the Pathogen Clostridioides difficile
M Neumann-Schaal, D Jahn… - Frontiers in …, 2019 - frontiersin.org
Strains of Clostridioides difficile cause detrimental diarrheas with thousands of deaths
worldwide. The infection process by the Gram-positive, strictly anaerobic gut bacterium is …
worldwide. The infection process by the Gram-positive, strictly anaerobic gut bacterium is …
[HTML][HTML] Major genetic discontinuity and novel toxigenic species in Clostridioides difficile taxonomy
Clostridioides difficile infection (CDI) remains an urgent global One Health threat. The
genetic heterogeneity seen across C. difficile underscores its wide ecological versatility and …
genetic heterogeneity seen across C. difficile underscores its wide ecological versatility and …
[HTML][HTML] In vivo commensal control of Clostridioides difficile virulence
BP Girinathan, N DiBenedetto, JN Worley, J Peltier… - Cell Host & Microbe, 2021 - cell.com
Leveraging systems biology approaches, we illustrate how metabolically distinct species of
Clostridia protect against or worsen Clostridioides difficile infection in mice by modulating …
Clostridia protect against or worsen Clostridioides difficile infection in mice by modulating …
The impact of pH on Clostridioides difficile sporulation and physiology
D Wetzel, SM McBride - Applied and environmental microbiology, 2020 - Am Soc Microbiol
Clostridioides difficile is a pathogenic bacterium that infects the human colon to cause
diarrheal disease. Growth of the bacterium is known to be dependent on certain bile acids …
diarrheal disease. Growth of the bacterium is known to be dependent on certain bile acids …
Responses of Clostridia to oxygen: from detoxification to adaptive strategies
Clostridia comprise bacteria of environmental, biotechnological and medical interest and
many commensals of the gut microbiota. Because of their strictly anaerobic lifestyle, oxygen …
many commensals of the gut microbiota. Because of their strictly anaerobic lifestyle, oxygen …
An RNA-centric global view of Clostridioides difficile reveals broad activity of Hfq in a clinically important gram-positive bacterium
M Fuchs, V Lamm-Schmidt, J Sulzer… - Proceedings of the …, 2021 - National Acad Sciences
The gram-positive human pathogen Clostridioides difficile has emerged as the leading
cause of antibiotic-associated diarrhea. However, little is known about the bacterium's …
cause of antibiotic-associated diarrhea. However, little is known about the bacterium's …
The battle for iron in enteric infections
A Sousa Gerós, A Simmons, H Drakesmith… - …, 2020 - Wiley Online Library
Iron is an essential element for almost all living organisms, but can be extremely toxic in high
concentrations. All organisms must therefore employ homeostatic mechanisms to finely …
concentrations. All organisms must therefore employ homeostatic mechanisms to finely …
Grad-seq identifies KhpB as a global RNA-binding protein in Clostridioides difficile that regulates toxin production
V Lamm-Schmidt, M Fuchs, J Sulzer, M Gerovac… - …, 2021 - academic.oup.com
Much of our current knowledge about cellular RNA–protein complexes in bacteria is derived
from analyses in gram-negative model organisms, with the discovery of RNA-binding …
from analyses in gram-negative model organisms, with the discovery of RNA-binding …
Glycine fermentation by C. difficile promotes virulence and spore formation, and is induced by host cathelicidin
A Rizvi, G Vargas-Cuebas, AN Edwards… - Infection and …, 2023 - Am Soc Microbiol
Clostridioides difficile is a leading cause of antibiotic-associated diarrheal disease. C.
difficile colonization, growth, and toxin production in the intestine is strongly associated with …
difficile colonization, growth, and toxin production in the intestine is strongly associated with …