The potential relationship between childhood obesity and earlier puberty onset has major
public health implications. Earlier menarche in girls is associated with increased risk of adult …

Background. The acceleration of pubertal development is an important medical and social
problem, as it may result in increased morbidity and mortality in later life. This systematic …

Ever since the publication of the first textbook on human growth by Johann Augustin Stoeller
in 1729, temporal changes (or secular trends) in growth and pubertal maturation have been …

A woman's age at menarche (first menstrual period) and her age at menopause are the
alpha and omega of her reproductive years. The timing of these milestones is critical for a …

Background: Early menarche increases breast cancer risk but, aside from weight,
information on its determinants is limited. Methods: Age at menarche data were collected …

Background Early menarche tends to be preceded by rapid infancy weight gain and is
associated with increased childhood and adult obesity risk. As age at menarche is a …

Background and objective Adiposity in pre‐and postnatal life may influence menarcheal
age. Existing evidence is primarily cross‐sectional, failing to address temporality, for which …

Puberty is a critical phase of growth and development characterized by a complex process
regulated by the neuroendocrine system. Precocious puberty (PP) is defined as the …

The early (intrauterine and neonatal) life environment plays an important role in
programming the susceptibility in later life to chronic degenerative diseases, such as …

Background Recently the prevalence of precocious puberty development is increasing
among Chinese children. Proper understanding of the risk factors for precocious puberty in …