In many asthmatics, chronic airway inflammation is driven by IL-4-, IL-5-, and IL-13-
producing Th2 cells or ILC2s. Type 2 cytokines promote hallmark features of the disease …

Pyroptosis, apoptosis and necroptosis are the most genetically well-defined programmed
cell death (PCD) pathways, and they are intricately involved in both homeostasis and …

Asthma is a chronic inflammatory airway disease associated with type 2 cytokines
interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus …

The impact of respiratory virus infections on the health of children and adults can be very
significant. Yet, in contrast to most other childhood infections as well as other viral and …

Background Studies of patients admitted to hospital with COVID-19 have found varying
mortality outcomes associated with underlying respiratory conditions and inhaled …

Abstract Angiotensin-converting enzyme 2 (ACE2) is the main entry point in airway epithelial
cells for SARS-CoV-2. ACE2 binding to the SARS-CoV-2 protein spike triggers viral fusion …

The molecular processes underlying human health and disease are highly complex. Often,
genetic and environmental factors contribute to a given disease or phenotype in a non …

Airway epithelial barrier dysfunction is frequently observed in asthma and may have
important implications. The physical barrier function of the airway epithelium is tightly …

Immune response in the asthmatic respiratory tract is mainly driven by CD4+ T helper (Th)
cells, represented by Th1, Th2, and Th17 cells, especially Th2 cells. Asthma is a …

Asthma is a common disease that affects 300 million people worldwide. Given the large
number of eosinophils in the airways of people with mild asthma, and verified by data from …