Respiratory infectious diseases encountered early in life may result in life-threatening
disease in neonates, which is primarily explained by the relatively naive neonatal immune …

Bacillus Calmette-Guérin (BCG) is an attenuated Mycobacterium bovis strain used as a
vaccine to prevent Mycobacterium tuberculosis (M. tb) infection. Its ability to potentiate the …

Alopecia areata (AA) is a non-scarring hair loss disorder caused by autoimmunity. The
immune collapse of the hair follicle, where interferon-gamma (IFN-γ) and CD8+ T cells …

Control of Mycobacterium tuberculosis (Mtb) infection requires generation of T cells that
migrate to granulomas, complex immune structures surrounding sites of bacterial replication …

Abstract γδ T cells provide rapid cellular immunity against pathogens. Here, we conducted
matched single-cell RNA-sequencing and γδ-TCR-sequencing to delineate the molecular …

Bacillus Calmette-Guerin (BCG) has been used as a vaccine against tuberculosis since
1921 and remains the only currently approved vaccine for this infection. The recent …

Bacille Calmette-Guérin (BCG) is the only approved vaccine for tuberculosis (TB) prevention
worldwide. BCG has an excellent protective effect on miliary tuberculosis and tuberculous …

Intravenously (IV) delivered BCG provides superior tuberculosis (TB) protection compared
with the intradermal (ID) route in non-human primates (NHPs). We examined how γδ T cell …

Immunization strategies against tuberculosis (TB) that confer better protection than neonatal
vaccination with the 101-year-old Bacille Calmette-Guerin (BCG) are urgently needed to …

The concept of donor-unrestricted T cells (DURTs) comprises a heterogeneity of lymphoid
cells that respond to an abundance of unconventional epitopes in a non-MHC-restricted …