Machine learning models to accelerate the design of polymeric long-acting injectables

P Bannigan, Z Bao, RJ Hickman, M Aldeghi… - Nature …, 2023 - nature.com
Long-acting injectables are considered one of the most promising therapeutic strategies for
the treatment of chronic diseases as they can afford improved therapeutic efficacy, safety …

Synthetic biodegradable polyesters for implantable controlled-release devices

JU Pothupitiya, C Zheng… - Expert Opinion on Drug …, 2022 - Taylor & Francis
Introduction Implantable devices can be designed to release drugs to localized regions of
tissue at sustained and reliable rates. Advances in polymer engineering have led to the …

Effects of the species of crosslinking reagents on the structures and properties of biodegradable poly (butanediol sebacate‐butanediol terephthalate) copolyester

Z Li, Y Li, M He, W Wang, J Li - Journal of Applied Polymer …, 2022 - Wiley Online Library
In the present study, poly (butylene sebacate‐co‐terephthalate) s having different
crosslinking reagents were synthesized with a random distribution by a two‐step …

Poly (δ-valerolactone-co-allyl-δ-valerolactone) cross-linked microparticles: Formulation, characterization and biocompatibility

Z Bao, S Jung, J Bufton, JC Evans, DJ Aguiar… - Journal of …, 2021 - Elsevier
A novel polymeric material, poly (δ-valerolactone-co-allyl-δ-valerolactone)(PVL-co-PAVL),
was used to manufacture microparticles (MPs) for sustained drug delivery. PVL-co-PAVL …

Introduction to immune responses toward medical implants

S Babykutty, P Suboj, S Udayan - Polymeric Materials for Biomedical …, 2024 - Elsevier
According to studies, 100% of all artificial implants trigger an immunological response, and
35% of them necessitate a second procedure. The extent to which the chosen biomaterial …

Polymer implants for gene and drug delivery

J Kumar, BS Unnikrishnan, M Narayan - Polymeric Materials for Biomedical …, 2024 - Elsevier
The effective management of diseases remains to be a great challenge to clinicians,
although different forms of novel compounds were identified as drugs. To improve the …

Tunable encapsulations: Droplet-based microfluidics for the expansion of biodegradable polymer technologies

DD Harrier - 2022 - ideals.illinois.edu
Environmental plastic pollution has become a cause for concern over the past decades,
motivated by an alarming accumulation of plastics in landfills and oceans. Biodegradable …