Mechanisms of drug resistance in HCC

AD Ladd, S Duarte, I Sahin, A Zarrinpar - Hepatology, 2024 - journals.lww.com
HCC comprises∼ 80% of primary liver cancer. HCC is the only major cancer for which death
rates have not improved over the last 10 years. Most patients are diagnosed with advanced …

The microenvironmental and metabolic aspects of sorafenib resistance in hepatocellular carcinoma

S Xia, Y Pan, Y Liang, J Xu, X Cai - EBioMedicine, 2020 - thelancet.com
In most cases, sorafenib-resistant HCC cells exhibit significant mesenchymal phenotype and
stemness features. In this context, tumor cells might undergo cell fate transition in response …

[HTML][HTML] Alkaloids from traditional Chinese medicine against hepatocellular carcinoma

C Liu, S Yang, K Wang, X Bao, Y Liu, S Zhou… - Biomedicine & …, 2019 - Elsevier
Hepatocellular carcinoma (HCC) has become one of the major diseases that are threatening
human health in the 21st century. Currently there are many approaches to treat liver cancer …

Sorafenib resistance in hepatocellular carcinoma: the relevance of genetic heterogeneity

LKD Cabral, C Tiribelli, CHC Sukowati - Cancers, 2020 - mdpi.com
Despite advances in biomedicine, the incidence and the mortality of hepatocellular
carcinoma (HCC) remain high. The majority of HCC cases are diagnosed in later stages …

Role of CD36 in cancer progression, stemness, and targeting

SL Guerrero-Rodríguez, C Mata-Cruz… - Frontiers in Cell and …, 2022 - frontiersin.org
CD36 is highly expressed in diverse tumor types and its expression correlates with
advanced stages, poor prognosis, and reduced survival. In cancer cells, CD36: 1) increases …

Sorafenib combined with STAT3 knockdown triggers ER stress-induced HCC apoptosis and cGAS-STING-mediated anti-tumor immunity

X Wang, R Hu, Z Song, H Zhao, Z Pan, Y Feng, Y Yu… - Cancer letters, 2022 - Elsevier
Sorafenib is the first-line treatment for advanced hepatocellular carcinoma (HCC). However,
it is difficult to alleviate this disease process using single-agent chemotherapy. Using …

[PDF][PDF] RETRACTED ARTICLE: IL-6/STAT3 Signaling Contributes to Sorafenib Resistance in Hepatocellular Carcinoma Through Targeting Cancer Stem Cells

Y Li, G Chen, Z Han, H Cheng, L Qiao… - OncoTargets and …, 2020 - Taylor & Francis
Li Y, Chen G, Han Z, Cheng H, Qiao L, Li Y. Onco Targets Ther. 2020; 13: 9721–9730. The
Editor and Publisher of OncoTargets and Therapy wish to retract the published article …

NOD2 inhibits tumorigenesis and increases chemosensitivity of hepatocellular carcinoma by targeting AMPK pathway

X Ma, Y Qiu, Y Sun, L Zhu, Y Zhao, T Li, Y Lin… - Cell death & …, 2020 - nature.com
Nucleotide binding oligomerization domain 2 (NOD2) is a recognized innate immune sensor
which can initiate potent immune response against pathogens. Many innate immune …

AMP-activated protein kinase: do we need activators or inhibitors to treat or prevent cancer?

FM Russell, DG Hardie - International Journal of Molecular Sciences, 2020 - mdpi.com
AMP-activated protein kinase (AMPK) is a key regulator of cellular energy balance. In
response to metabolic stress, it acts to redress energy imbalance through promotion of ATP …

[HTML][HTML] Divergent processing of cell stress signals as the basis of cancer progression: Licensing NFκB on Chromatin

SA Vlahopoulos - International Journal of Molecular Sciences, 2024 - mdpi.com
Inflammation is activated by diverse triggers that induce the expression of cytokines and
adhesion molecules, which permit a succession of molecules and cells to deliver stimuli and …