Dopamine (DA) is the most important catecholamine in the brain, as it is the most abundant
and the precursor of other neurotransmitters. Degeneration of nigrostriatal neurons of …

There are a group of diseases associated with protein misfolding and accumulation into
amyloid fibers. Many of these diseases have a major impact on human health, in particular …

Peptides are versatile and powerful ligands to form stable complexes with the great majority
of metal ions. The outstanding stability of peptide complexes is, however, linked to the …

The review describes the state of the art in the field of stability constant determination for Cu
(II), Cu (I) and Zn (II) complexes of proteins and peptides involved in neurodegenerative …

Numerous studies have demonstrated the high metal binding capacity and selectivity of
peptide molecules. The terminal amino group, deprotonated amide nitrogens, and various …

In this review we give an updated outlook of the reactivity of catecholamines, particularly
dopamine, and the redox effects produced by their interaction with copper (II) and dioxygen …

Metal ions, especially redox active copper, are thought to play critical roles in
neurodegenerative disorders. As a matter of fact, metal binding may result into severe …

Copper is reported to promote and prevent aggregation of prion protein. Conformational and
functional consequences of Cu 2+-binding to prion protein (PrP) are not well understood …

The cellular isoform of the prion protein PrP C is a Cu 2+-binding cell surface glycoprotein
that, when misfolded, is responsible for a range of transmissible spongiform …

The review describes the stability and the coordination modes of Cu2+ complexes with
different regions of N-terminus prion proteins. The structural features of the different metal …