Atherosclerotic cardiovascular (CV) disease (ASCVD) incidence and mortality rates are
declining in many countries in Europe, but it is still a major cause of morbidity and mortality …

Recurrent stroke affects 9% to 15% of people within 1 year. This European Stroke
Organisation (ESO) guideline provides evidence-based recommendations on …

Aims The expression of GADD153 (growth arrest and DNA damage-inducible gene 153), an
apoptosis-regulated gene, increases during endoplasmic reticulum (ER) stress. How …

Background In the PATHWAY-2 study of resistant hypertension, spironolactone reduced
blood pressure substantially more than conventional antihypertensive drugs. We did three …

Primary aldosteronism (PA) due to a unilateral aldosterone-producing adenoma is a
common cause of hypertension. This can be cured, or greatly improved, by adrenal surgery …

Importance Poorly controlled hypertension is a leading global public health problem
requiring new treatment strategies. Objective To assess whether a low-dose triple …

Objective: To assess the efficacy and tolerability of dual combination of blood pressure (BP)-
lowering drugs as initial treatment for hypertension. Methods: MEDLINE, Embase …

Background Hypertension remains a significant modifiable risk factor for cardiovascular
diseases and a major determinant of morbidity and mortality. We aimed to describe sex …

Hypertension is the leading risk factor for cardiovascular disease (CVD) worldwide. Despite
the availability of effective antihypertensive medications, the control of hypertension at a …

Objective: The 2018 European Society of Cardiology/European Society of Hypertension
Guidelines for the management of arterial hypertension raised the need for evidence to …