Valproic acid (VPA), a branched short‐chain fatty acid, is widely used as an antiepileptic
drug and a mood stabilizer. Antiepileptic properties have been attributed to inhibition of …

Cancer stem cells (CSCs) are a subpopulation of tumor cells that selectively possess tumor
initiation and self-renewal capacity and the ability to give rise to bulk populations of …

Tumour-initiating cells capable of self-renewal and differentiation, which are responsible for
tumour growth, have been identified in human haematological malignancies, and solid …

In the last years, mortality from breast cancer has declined in western countries as a
consequence of a more widespread screening resulting in earlier detection, as well as an …

Although breast cancer is a heterogeneous disease that is challenging to characterize and
treat, the recent explosion of genetic and epigenetic research may help improve these …

Epigenetic treatment has been approved by regulatory agencies for haematological
malignancies. The success observed in cutaneous lymphomas represents a proof of …

Panobinostat (pano) is an FDA-approved histone deacetylase inhibitor. There is interest in
evaluating alternate dosing schedules and novel combinations of pano for the treatment of …

Epigenetic silencing of immune-related genes is a striking feature of the cancer genome that
occurs in the process of tumorigenesis. This phenomena impacts antigen processing and …

Among many anticancer drugs collectively named “targeted or molecular therapies”
epigenetic drugs are clearly promising. Differently from other agents targeting a single gene …

Epigenetic inactivation of pivotal genes involved in correct cell growth is a hallmark of
human pathologies, in particular cancer. These epigenetic mechanisms, including crosstalk …