Neuronally derived extracellular vesicle α-synuclein as a serum biomarker for individuals at risk of developing Parkinson disease
IMPORTANCE Nonmotor symptoms of Parkinson disease (PD) often predate the movement
disorder by decades. Currently, there is no blood biomarker to define this prodromal phase …
disorder by decades. Currently, there is no blood biomarker to define this prodromal phase …
Biosensing strategies for amyloid‐like protein aggregates
Y Zhou, S Yan, W Dong, C Wu, Z Zhao, R Wang… - …, 2024 - Wiley Online Library
Protein aggregate species play a pivotal role in the pathology of various degenerative
diseases. Their dynamic changes are closely correlated with disease progression, making …
diseases. Their dynamic changes are closely correlated with disease progression, making …
[HTML][HTML] Molecular insights into aggrephagy: Their cellular functions in the context of neurodegenerative diseases
VC Segovia, F Reggiori - Journal of Molecular Biology, 2024 - Elsevier
Protein homeostasis or proteostasis is an equilibrium of biosynthetic production, folding and
transport of proteins, and their timely and efficient degradation. Proteostasis is guaranteed …
transport of proteins, and their timely and efficient degradation. Proteostasis is guaranteed …
[HTML][HTML] Neuronal activity promotes secretory autophagy for the extracellular release of α-synuclein
Y Nakamura, T Sawai, K Kakiuchi, S Arawaka - Journal of Biological …, 2024 - Elsevier
Extracellular secretion is an essential mechanism for α-synuclein (α-syn) proteostasis.
Although it was reported that neuronal activity affects α-syn secretion, the underlying …
Although it was reported that neuronal activity affects α-syn secretion, the underlying …
Mono-UFMylation promotes misfolding-associated secretion of α-synuclein
L Wang, Y Xu, T Fukushige, L Saidi, X Wang, C Yu… - Science …, 2024 - science.org
Stressed cells secret misfolded proteins lacking signaling sequence via an unconventional
protein secretion (UcPS) pathway, but how misfolded proteins are targeted selectively in …
protein secretion (UcPS) pathway, but how misfolded proteins are targeted selectively in …
[HTML][HTML] The αSynuclein half-life conundrum
Abstract αSynuclein (αSyn) misfolding and aggregation frequently precedes neuronal loss
associated with Parkinson's Disease (PD) and other Synucleinopathies. The progressive …
associated with Parkinson's Disease (PD) and other Synucleinopathies. The progressive …
Alpha-Synuclein and GM1 Ganglioside Co-Localize in Neuronal Cytosol Leading to Inverse Interaction—Relevance to Parkinson's Disease
R Kumar, S Chowdhury, R Ledeen - International journal of molecular …, 2024 - mdpi.com
Research on GM1 ganglioside and its neuroprotective role in Parkinson's disease (PD),
particularly in mitigating the aggregation of α-Synuclein (aSyn), is well established across …
particularly in mitigating the aggregation of α-Synuclein (aSyn), is well established across …
Aquaporin-4 and Parkinson's Disease
KV Lapshina, IV Ekimova - International Journal of Molecular Sciences, 2024 - mdpi.com
The water-selective channel aquaporin-4 (AQP4) is implicated in water homeostasis and the
functioning of the glymphatic system, which eliminates various metabolites from the brain …
functioning of the glymphatic system, which eliminates various metabolites from the brain …
ESCRT-III: a versatile membrane remodeling machinery and its implications in cellular processes and diseases
J Park, J Kim, H Park, T Kim, S Lee - Animal Cells and Systems, 2024 - Taylor & Francis
The endosomal sorting complexes required for transport (ESCRT) machinery is an
evolutionarily conserved cytosolic protein complex that plays a crucial role in membrane …
evolutionarily conserved cytosolic protein complex that plays a crucial role in membrane …
[PDF][PDF] Molecular Insights into Aggrephagy: Their Cellular Functions in the Context of Neurodegenerative Diseases
V Coppola-Segovia, F Reggiori - 2024 - researchgate.net
Protein homeostasis or proteostasis is an equilibrium of biosynthetic production, folding and
transport of proteins, and their timely and efficient degradation. Proteostasis is guaranteed …
transport of proteins, and their timely and efficient degradation. Proteostasis is guaranteed …