Uremic toxins in the progression of chronic kidney disease and cardiovascular disease: mechanisms and therapeutic targets
YJ Lim, NA Sidor, NC Tonial, A Che, BL Urquhart - Toxins, 2021 - mdpi.com
Chronic kidney disease (CKD) is a progressive loss of renal function. The gradual decline in
kidney function leads to an accumulation of toxins normally cleared by the kidneys, resulting …
kidney function leads to an accumulation of toxins normally cleared by the kidneys, resulting …
Gut-derived protein-bound uremic toxins
AL Graboski, MR Redinbo - Toxins, 2020 - mdpi.com
Chronic kidney disease (CKD) afflicts more than 500 million people worldwide and is one of
the fastest growing global causes of mortality. When glomerular filtration rate begins to fall …
the fastest growing global causes of mortality. When glomerular filtration rate begins to fall …
Interaction between a water-soluble anionic porphyrin and human serum albumin unexpectedly stimulates the aggregation of the photosensitizer at the surface of the …
A Costa-Tuna, OA Chaves, RJS Loureiro… - International Journal of …, 2024 - Elsevier
Abstract The 5, 10, 15, 20-tetrakis (2, 6-difluoro-3-sulfophenyl) porphyrin (TDFPPS 4) was
reported as a potential photosensitizer for photodynamic therapy. The capacity of the …
reported as a potential photosensitizer for photodynamic therapy. The capacity of the …
Uraemic solutes as therapeutic targets in CKD-associated cardiovascular disease
JD Ravid, MH Kamel, VC Chitalia - Nature Reviews Nephrology, 2021 - nature.com
Chronic kidney disease (CKD) is characterized by the retention of a myriad of solutes termed
uraemic (or uremic) toxins, which inflict damage to several organs, including the …
uraemic (or uremic) toxins, which inflict damage to several organs, including the …
Insight into the binding mechanism of imipenem to human serum albumin by spectroscopic and computational approaches
The mechanism of interaction between imipenem and HSA was investigated by various
techniques like fluorescence, UV–vis absorbance, FRET, circular dichroism, urea …
techniques like fluorescence, UV–vis absorbance, FRET, circular dichroism, urea …
MARK4 inhibited by AChE inhibitors, donepezil and Rivastigmine tartrate: insights into Alzheimer's disease therapy
Microtubule affinity-regulating kinase (MARK4) plays a key role in Alzheimer's disease (AD)
development as its overexpression is directly linked to increased tau phosphorylation …
development as its overexpression is directly linked to increased tau phosphorylation …
Biophysical and molecular docking insight into the interaction of cytosine β-D arabinofuranoside with human serum albumin
P Alam, SK Chaturvedi, T Anwar, MK Siddiqi… - Journal of …, 2015 - Elsevier
Interaction of pharmacologically important anticancer drug cytosine β-D arabinofuranoside
with human serum albumin (HSA) at physiological pH 7.4 has been studied by utilizing …
with human serum albumin (HSA) at physiological pH 7.4 has been studied by utilizing …
Myricetin inhibits breast and lung cancer cells proliferation via inhibiting MARK4
Identifying novel molecules as potential kinase inhibitors are gaining significant attention
globally. The present study suggests Myricetin as a potential inhibitor of microtubule‐affinity …
globally. The present study suggests Myricetin as a potential inhibitor of microtubule‐affinity …
Understanding the binding between Rosmarinic acid and serum albumin: In vitro and in silico insight
Rosmarinic acid (RA) is a natural product that is increasingly being used in food industries
and cosmetic industries. Drug pharmacokinetics is affected upon binding with protein, thus …
and cosmetic industries. Drug pharmacokinetics is affected upon binding with protein, thus …
Biophysical characterization of the interaction between a transport human plasma protein and the 5, 10, 15, 20-tetra (pyridine-4-yl) porphyrin
The interaction between human serum albumin (HSA) and the non-charged synthetic
photosensitizer 5, 10, 15, 20-tetra (pyridine-4-yl) porphyrin (4-TPyP) was evaluated by in …
photosensitizer 5, 10, 15, 20-tetra (pyridine-4-yl) porphyrin (4-TPyP) was evaluated by in …