Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review
WY Fang, L Ravindar, KP Rakesh… - European Journal of …, 2019 - Elsevier
At present more than 250 FDA approved chlorine containing drugs were available in the
market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is …
market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is …
Rational approaches, design strategies, structure activity relationship and mechanistic insights for therapeutic coumarin hybrids
Hybrid molecules, furnished by combining two or more pharmacophores is an emerging
concept in the field of medicinal chemistry and drug discovery that has attracted substantial …
concept in the field of medicinal chemistry and drug discovery that has attracted substantial …
Pharmaceutical significance of azepane based motifs for drug discovery: A critical review
Azepane-based compounds showed a variety of pharmacological properties, and its
derivatives possess a high degree of structural diversity, and it is useful for the discovery of …
derivatives possess a high degree of structural diversity, and it is useful for the discovery of …
Fabrication of hemocompatible chitosan-biogenic silver nanocomposite for biomedical applications
P Oviya, AP Francis, B Mahalaxmi - Journal of Drug Delivery Science and …, 2023 - Elsevier
Marine sources provide the biomass to meet the needs of the fast-growing world population
from diminishing terrestrial-based resources. In the past few decades, integrating marine …
from diminishing terrestrial-based resources. In the past few decades, integrating marine …
Synthesis, docking and evaluation of in vitro anti-inflammatory activity of novel morpholine capped β-lactam derivatives
This study reports the synthesis and biological investigation of three series of novel
monocyclic β-lactam derivatives bearing a morpholine ring substituent on the nitrogen. The …
monocyclic β-lactam derivatives bearing a morpholine ring substituent on the nitrogen. The …
Repurposing mosloflavone/5, 6, 7-trimethoxyflavone-resveratrol hybrids: Discovery of novel p38-α MAPK inhibitors as potent interceptors of macrophage-dependent …
AHE Hassan, SY Yoo, KW Lee, YM Yoon… - European journal of …, 2019 - Elsevier
Herein, we address repurposing hybrids of mosloflavone or 5, 6, 7-trimethoxyflavone with
amide analogs of resveratrol from anticancer leads to novel potent anti-inflammatory …
amide analogs of resveratrol from anticancer leads to novel potent anti-inflammatory …
Synthesis and characterization of biologically active flurbiprofen amide derivatives as selective prostaglandin-endoperoxide synthase II inhibitors: In vivo anti …
A novel series of twenty two flurbiprofen amides (1− 22) were designed and synthesized in
good to excellent yields by reacting flurbiprofen acid with various aromatic/aliphatic primary …
good to excellent yields by reacting flurbiprofen acid with various aromatic/aliphatic primary …
Chitosan/calcium nanoparticles as advanced antimicrobial coating for paper documents
Preservation of paper-based historical artifacts against deterioration due to the presence of
bacteria and fungi colonies has been one of the major issues for the importance of …
bacteria and fungi colonies has been one of the major issues for the importance of …
Anti-inflammatory drug approach: Synthesis and biological evaluation of novel pyrazolo [3, 4-d] pyrimidine compounds
In this study, the acid chlorides of pyrazolo [3, 4-d] pyrimidine compounds were prepared
and reacted with a number of nucleophiles. The novel compounds were experimentally …
and reacted with a number of nucleophiles. The novel compounds were experimentally …
Synthesis, structural characterization, and thermal studies of 3d-metal complexes derived from a thiazole-based ligand: Multifaceted biological properties and …
A novel series of 3d metal (Co (II), Ni (II), Cu (II) and Zn (II)) complexes derived from a N-(2-
chlorophenyl)-2-(1, 3-thiazol-2-ylamino) acetamide (CTA) ligand was reported and …
chlorophenyl)-2-(1, 3-thiazol-2-ylamino) acetamide (CTA) ligand was reported and …