Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review

WY Fang, L Ravindar, KP Rakesh… - European Journal of …, 2019 - Elsevier
At present more than 250 FDA approved chlorine containing drugs were available in the
market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is …

Rational approaches, design strategies, structure activity relationship and mechanistic insights for therapeutic coumarin hybrids

H Singh, JV Singh, K Bhagat, HK Gulati… - Bioorganic & medicinal …, 2019 - Elsevier
Hybrid molecules, furnished by combining two or more pharmacophores is an emerging
concept in the field of medicinal chemistry and drug discovery that has attracted substantial …

Pharmaceutical significance of azepane based motifs for drug discovery: A critical review

GF Zha, KP Rakesh, HM Manukumar… - European Journal of …, 2019 - Elsevier
Azepane-based compounds showed a variety of pharmacological properties, and its
derivatives possess a high degree of structural diversity, and it is useful for the discovery of …

Fabrication of hemocompatible chitosan-biogenic silver nanocomposite for biomedical applications

P Oviya, AP Francis, B Mahalaxmi - Journal of Drug Delivery Science and …, 2023 - Elsevier
Marine sources provide the biomass to meet the needs of the fast-growing world population
from diminishing terrestrial-based resources. In the past few decades, integrating marine …

Synthesis, docking and evaluation of in vitro anti-inflammatory activity of novel morpholine capped β-lactam derivatives

R Heiran, S Sepehri, A Jarrahpour, C Digiorgio… - Bioorganic …, 2020 - Elsevier
This study reports the synthesis and biological investigation of three series of novel
monocyclic β-lactam derivatives bearing a morpholine ring substituent on the nitrogen. The …

Repurposing mosloflavone/5, 6, 7-trimethoxyflavone-resveratrol hybrids: Discovery of novel p38-α MAPK inhibitors as potent interceptors of macrophage-dependent …

AHE Hassan, SY Yoo, KW Lee, YM Yoon… - European journal of …, 2019 - Elsevier
Herein, we address repurposing hybrids of mosloflavone or 5, 6, 7-trimethoxyflavone with
amide analogs of resveratrol from anticancer leads to novel potent anti-inflammatory …

Synthesis and characterization of biologically active flurbiprofen amide derivatives as selective prostaglandin-endoperoxide synthase II inhibitors: In vivo anti …

A Alam, M Ali, NU Rehman, A Latif, AJ Shah… - International Journal of …, 2023 - Elsevier
A novel series of twenty two flurbiprofen amides (1− 22) were designed and synthesized in
good to excellent yields by reacting flurbiprofen acid with various aromatic/aliphatic primary …

Chitosan/calcium nanoparticles as advanced antimicrobial coating for paper documents

AC Egil, B Ozdemir, SK Gunduz… - International Journal of …, 2022 - Elsevier
Preservation of paper-based historical artifacts against deterioration due to the presence of
bacteria and fungi colonies has been one of the major issues for the importance of …

Anti-inflammatory drug approach: Synthesis and biological evaluation of novel pyrazolo [3, 4-d] pyrimidine compounds

N Atatreh, AM Youssef, MA Ghattas, M Al Sorkhy… - Bioorganic …, 2019 - Elsevier
In this study, the acid chlorides of pyrazolo [3, 4-d] pyrimidine compounds were prepared
and reacted with a number of nucleophiles. The novel compounds were experimentally …

Synthesis, structural characterization, and thermal studies of 3d-metal complexes derived from a thiazole-based ligand: Multifaceted biological properties and …

L Afroz, M Khan, HM Vagdevi, M Azam, SA Adhoni… - Polyhedron, 2023 - Elsevier
A novel series of 3d metal (Co (II), Ni (II), Cu (II) and Zn (II)) complexes derived from a N-(2-
chlorophenyl)-2-(1, 3-thiazol-2-ylamino) acetamide (CTA) ligand was reported and …