The impact of oxidative stress on pediatrics syndromes

G Micangeli, M Menghi, G Profeta, F Tarani, A Mariani… - Antioxidants, 2022 - mdpi.com
Oxidative stress is a condition determined by an imbalance between antioxidant and
oxidative factors. Oxidative stress can have serious consequences on our organism. Indeed …

[HTML][HTML] A multi‐organ analysis of the role of mTOR in fetal alcohol spectrum disorders

AL Carabulea, JD Janeski, VD Naik, K Chen… - The FASEB …, 2023 - ncbi.nlm.nih.gov
Alcohol exposure during gestation can lead to fetal alcohol spectrum disorders (FASD), an
array of cognitive and physical developmental impairments. Over the past two and a half …

Dose-related shifts in proteome and function of extracellular vesicles secreted by fetal neural stem cells following chronic alcohol exposure

DD Chung, MR Pinson, AH Mahnke, NA Salem, KT Le… - Heliyon, 2022 - cell.com
Accumulating evidence indicates that extracellular vesicles (EVs) mediate endocrine
functions and also pathogenic effects of neurodevelopmental perturbagens like ethanol. We …

Rapamycin improves recognition memory and normalizes amino-acids and amines levels in the hippocampal dentate gyrus in adult rats exposed to ethanol during the …

M Lopatynska-Mazurek, A Pankowska… - Biomolecules, 2021 - mdpi.com
The mammalian target of rapamycin (mTOR), a serine/threonine kinase, is implicated in
synaptic plasticity by controlling protein synthesis. Research suggests that ethanol exposure …

Aversive learning deficits and depressive-like behaviors are accompanied by an increase in oxidative stress in a rat model of fetal alcohol spectrum disorders: The …

M Lopatynska-Mazurek, L Komsta… - International Journal of …, 2021 - mdpi.com
Fetal alcohol spectrum disorders (FASDs) are one of the most common consequences of
ethanol exposure during pregnancy. In adulthood, these disorders can be manifested by …

Impact of alcohol abuse on susceptibility to rare neurodegenerative diseases

I Araujo, A Henriksen, J Gamsby… - Frontiers in Molecular …, 2021 - frontiersin.org
Despite the prevalence and well-recognized adverse effects of prenatal alcohol exposure
and alcohol use disorder in the causation of numerous diseases, their potential roles in the …

Recent Breakthroughs in Understanding the Cerebellum's Role in Fetal Alcohol Spectrum Disorder: A Systematic Review

ECH Leung, P Jain, MA Michealson, H Choi… - Alcohol, 2023 - Elsevier
Exposure to alcohol during fetal development can lead to structural and functional
abnormalities in the cerebellum, a brain region responsible for motor coordination, balance …

Morphological alteration in rat hippocampal neuronal dendrites following chronic binge prenatal alcohol exposure

J Lee, V Naik, M Orzabal, R Lunde-Young… - Brain research, 2021 - Elsevier
Prenatal alcohol exposure (PAE) may result in Fetal Alcohol Spectrum Disorders (FASD).
The hippocampus has been recognized as a vulnerable target to alcohol-induced …

Oxidative Effects in Early Stages of Embryo Development Due to Alcohol Consumption

D González-Flores, A Márquez, I Casimiro - International Journal of …, 2024 - mdpi.com
Alcohol, a widely consumed drug, exerts significant toxic effects on the human organism.
This review focuses on its impact during fetal development, when it leads to a spectrum of …

In Vivo Administration of Phosphatidic Acid, a Direct Alcohol Target Rescues Fetal Growth Restriction and Maternal Uterine Artery Dysfunction in Rat FASD Model

JD Janeski, VD Naik, AL Carabulea, H Jiang… - Nutrients, 2024 - mdpi.com
Fetal growth restriction is a hallmark of Fetal Alcohol Syndrome (FAS) and is accompanied
by maternal uterine circulatory maladaptation. FAS is the most severe form of Fetal Alcohol …