In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

The endocannabinoid (eCB) system has emerged as a central integrator linking the
perception of external and internal stimuli to distinct neurophysiological and behavioural …

The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a
key component of pain and inflammation. A large amount of evidence shows that TRPV1 is …

As the brain‐resident innate immune cells, reactive microglia are a major pathological
feature of Alzheimer's disease (AD). However, the exact role of microglia is still unclear in …

Capsaicin is a natural compound found in chili peppers and is used in the diet of many
countries. The important mechanism of action of capsaicin is its influence on TRPV1 …

Persistent CB1 cannabinoid receptor activity limits neurotransmitter release at various
synapses throughout the brain. However, it is not fully understood how constitutively active …

The endogenous cannabinoid transmitter system regulates synaptic transmission
throughout the nervous system. Unlike conventional transmitters, specific stimuli induce …

TRPV1 has been originally cloned as the heat and capsaicin receptor implicated in acute
pain signalling, while further research has shifted the focus to its importance in chronic pain …

Dentate gyrus of the hippocampus continuously gives rise to new neurons, namely, adult-
born granule cells, which contribute to conferring plasticity to the mature brain throughout …

The ongoing epidemics of metabolic diseases and increase in the older population have
increased the incidences of neurodegenerative diseases. Evidence from murine and cell …