Bacterial stress responses during host infection

FC Fang, ER Frawley, T Tapscott, A Vázquez-Torres - Cell host & microbe, 2016 - cell.com
Pathogenic bacteria must withstand diverse host environments during infection.
Environmental signals, such as pH, temperature, nutrient limitation, etc., not only trigger …

Mechanisms of bacterial tolerance and persistence in the gastrointestinal and respiratory environments

R Trastoy, T Manso, L Fernández-García… - Clinical microbiology …, 2018 - Am Soc Microbiol
Pathogens that infect the gastrointestinal and respiratory tracts are subjected to intense
pressure due to the environmental conditions of the surroundings. This pressure has led to …

(p) ppGpp metabolism and antimicrobial resistance in bacterial pathogens

B Das, RK Bhadra - Frontiers in Microbiology, 2020 - frontiersin.org
Single cell microorganisms including pathogens relentlessly face myriads of
physicochemical stresses in their living environment. In order to survive and multiply under …

Cyclic diguanylate signaling in Gram-positive bacteria

EB Purcell, R Tamayo - FEMS microbiology reviews, 2016 - academic.oup.com
The nucleotide second messenger 3′-5′ cyclic diguanylate monophosphate (c-di-GMP) is
a central regulator of the transition between motile and non-motile lifestyles in bacteria …

Genomic analysis of Acinetobacter baumannii prophages reveals remarkable diversity and suggests profound impact on bacterial virulence and fitness

AR Costa, R Monteiro, J Azeredo - Scientific Reports, 2018 - nature.com
The recent nomination by the World Health Organization of Acinetobacter baumannii as the
number one priority pathogen for the development of new antibiotics is a direct …

The stringent response regulator DksA is required for Salmonella enterica serovar Typhimurium growth in minimal medium, motility, biofilm formation, and intestinal …

S Azriel, A Goren, G Rahav, O Gal-Mor - Infection and immunity, 2016 - Am Soc Microbiol
Salmonella enterica serovar Typhimurium is a facultative intracellular human and animal
bacterial pathogen posing a major threat to public health worldwide. Salmonella …

QstR-dependent regulation of natural competence and type VI secretion in Vibrio cholerae

M Jaskolska, S Stutzmann, C Stoudmann… - Nucleic acids …, 2018 - academic.oup.com
During growth on chitinous surfaces in its natural aquatic environment Vibrio cholerae
develops natural competence for transformation and kills neighboring non-immune bacteria …

Guanosine tetra-and pentaphosphate increase antibiotic tolerance by reducing reactive oxygen species production in Vibrio cholerae

HY Kim, J Go, KM Lee, YT Oh, SS Yoon - Journal of Biological Chemistry, 2018 - ASBMB
The pathogen Vibrio cholerae is the causative agent of cholera. Emergence of antibiotic-
resistant V. cholerae strains is increasing, but the underlying mechanisms remain unclear …

Asymmetric regulation of quorum-sensing receptors drives autoinducer-specific gene expression programs in Vibrio cholerae

A Hurley, BL Bassler - PLoS genetics, 2017 - journals.plos.org
Quorum sensing (QS) is a mechanism of chemical communication that bacteria use to
monitor cell-population density and coordinate group behaviors. QS relies on the …

Stringent response regulators (p)ppGpp and DksA positively regulate virulence and host adaptation of Xanthomonas citri

Y Zhang, D Teper, J Xu, N Wang - Molecular plant pathology, 2019 - Wiley Online Library
The bacterial stringent response is a response to nutrition deprivation and other stress
conditions. In Gram‐negative bacteria, this process is mediated by the small signal …