The dream to prepare well-defined materials drives the methodological evolution for
molecular synthesis, structural control and materials manufacturing. Among various …

Studies of bioactive lipids in general and sphingolipids in particular have intensified over the
past several years, revealing an unprecedented and unanticipated complexity of the …

Two-thirds of human hormones and one-third of clinical drugs activate~ 350 G-protein-
coupled receptors (GPCR) belonging to four classes: A, B1, C and F. Whereas a model of …

Structures of 70 unique G protein-coupled receptors (GPCRs) have been determined, with
over 370 structures in total bound to different ligands and the receptors in various …

BACKGROUND Sphingosine 1-phosphate (S1P), a product of membrane sphingolipid
metabolism, is secreted and acts through G protein–coupled S1P receptors (S1PRs) in …

Abstract Cannabinoid CB2 receptor (CB2R) agonists are investigated as therapeutic agents
in the clinic. However, their molecular mode-of-action is not fully understood. Here, we report …

Cannabis elicits its mood-enhancing and analgesic effects through the cannabinoid receptor
1 (CB1), a G protein-coupled receptor (GPCR) that signals primarily through the adenylyl …

The cannabinoid receptor CB2 is predominately expressed in the immune system, and
selective modulation of CB2 without the psychoactivity of CB1 has therapeutic potential in …

Individual free fatty acids (FAs) play important roles in metabolic homeostasis, many through
engagement with more than 40G protein–coupled receptors. Searching for receptors to …

Abstract The cannabinoid receptor 1 (CB1) is the principal target of the psychoactive
constituent of marijuana, the partial agonist Δ9-tetrahydrocannabinol (Δ9-THC). Here we …